PMID

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Article Title

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Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.

Northwestern University

Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.

Northwestern University

Virtual High-Throughput Screening To Identify Novel Activin Antagonists.

Northwestern University

2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.

Northwestern University

Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.

Northwestern University

Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.

Northwestern University

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.

Northwestern University

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Northwestern University

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.

Northwestern University

An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.

Northwestern University

In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.

Northwestern University

Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.

Northwestern University

Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.

Northwestern University

Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Northwestern University

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Probing the steric requirements of the¿-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.

Northwestern University

(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent¿-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.

Northwestern University

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

Northwestern University

Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase.

Northwestern University

Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase.

Northwestern University

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.

Northwestern University

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Kinase inhibitors: not just for kinases anymore.

Northwestern University

Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.

Northwestern University

Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Northwestern University

A specific mechanism of nonspecific inhibition.

Northwestern University

A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.

Northwestern University

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.

Northwestern University

Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.

Northwestern University

N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.

Northwestern University

Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.

Northwestern University

Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation.

Northwestern University

5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators.

Northwestern University

Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.

Northwestern University

1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.

Northwestern University

Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.

Northwestern University

Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis.

Northwestern University

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

Northwestern University

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Northwestern University

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Northwestern University

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.

Northwestern University

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.

Northwestern University

L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.

Northwestern University

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Northwestern University

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

Northwestern University

Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma.

Northwestern University

Medicinal chemistry approaches to target the MNK-eIF4E axis in cancer.

Northwestern University

Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2).

Northwestern University

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.

Northwestern University

Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors.

Northwestern University

Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors.

Northwestern University

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Northwestern University

Discovery of Highly Potent Serotonin 5-HT

Northwestern University

2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

Northwestern University

Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma.

Northwestern University

Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.

Northwestern University

Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer.

Northwestern University

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase.

Northwestern University

Non-'classical' MEKs: A review of MEK3-7 inhibitors.

Northwestern University

Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues.

Northwestern University

Structure-based approach for binding site identification on AmpC beta-lactamase.

Northwestern University

A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of gamma-aminobutyric acid aminotransferase.

Northwestern University

Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.

Northwestern University

Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.

Northwestern University

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase.

Northwestern University

Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands.

Northwestern University

2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid.

Northwestern University

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.

Northwestern University

4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators.

Northwestern University

Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues.

Northwestern University

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Northwestern University

Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologues of primary amine substrates.

Northwestern University

Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide).

Northwestern University

Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression.

Northwestern University

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Northwestern University

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

Northwestern University

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine.

Northwestern University

2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase.

Northwestern University

Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase.

Northwestern University

Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids.

Northwestern University

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Northwestern University

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.

Northwestern University

LRRK2 inhibiting compounds and use thereof for treating neurodegenerative diseases

Consejo Superior De Investigaciones Cientificas

SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF

The Johns Hopkins University

Functionalized peptides as antiviral agents

Enanta Pharmaceuticals

Oxazoline pseudodimers, pharmaceutical compositions and the use thereof

Purdue Pharma

Heterocyclic compounds as immunomodulators

Incyte

Adenosine A3 receptor modulators

Palobiofarma

Quinazoline derivatives substituted by aniline, preparation method and use thereof

Xuanzhu Pharma

Compounds for the treatment of hepatitis C

Bristol-Myers Squibb

Triazolopyridazine

Boehringer Ingelheim International

5-HT3 receptor antagonists

Takeda Pharmaceutical

Pharmaceutical composition for treating diabetes

Ajinomoto

Aminoheteroaryl benzamides as kinase inhibitors

Novartis

N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia

Pfizer

Management and treatment of benign prostatic hyperplasia

CSIR, Pretoria (Za)

Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli.

University of Wisconsin

Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position.

R & D, Zambon Group

Alpha-1 adrenergic receptor binding in aortas from rat and dog: comparison of [3H]prazosin and beta-iodo-[125I]-4-hydroxyphenyl-ethyl-aminomethyl-tetralone.

Unwersity of Misscuri

The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.

Polish Academy of Sciences

Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties.

Astrazeneca

BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.

Merck Research Laboratories

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Merck Research Laboratories

Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.

German Cancer Research Center

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors.

Glaxosmithkline