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Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.

National Taiwan University

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.

National Taiwan University

Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor.

National Taiwan University

Tamiphosphor monoesters as effective anti-influenza agents.

National Taiwan University

Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.

National Taiwan University

Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.

National Taiwan University

Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.

National Taiwan University

Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein.

National Taiwan University

Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation.

National Taiwan University

Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.

National Taiwan University

Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.

National Taiwan University

Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus.

National Taiwan University

Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.

National Taiwan University

Selective reversible and irreversible ligands for the kappa opioid receptor.

National Taiwan University

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.

National Taiwan University

Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.

National Taiwan University

Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolines.

National Taiwan University

Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.

National Taiwan University

Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B.

National Taiwan University

Litebamine N-homologues: preparation and anti-acetylcholinesterase activity.

National Taiwan University

Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition.

National Taiwan University

Isolation of Anti-SARS-CoV-2 Natural Products Extracted from

National Taiwan University

Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis.

National Taiwan University

Preparation of secolycorines against acetylcholinesterase.

National Taiwan University

Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation.

National Taiwan University

Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.

National Taiwan University

Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.

National Taiwan University

C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.

National Taiwan University

Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.

National Taiwan University

Enhanced anti-influenza agents conjugated with anti-inflammatory activity.

National Taiwan University

Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir.

National Taiwan University

Six lignans from Phyllanthus myrtifolius.

National Taiwan University

Peramivir conjugates as orally available agents against influenza H275Y mutant.

National Taiwan University

Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties.

National Taiwan University

Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.

National Taiwan University

Targeting breast cancer stem cells by novel HDAC3-selective inhibitors.

National Taiwan University

2-(morpholin-4-yl)-1,7-naphthyridines

Bayer Pharma Aktiengesellschaft

2,4-disubstituted pyrimidines as CDK inhibitors

Shanghai Xunhe Pharmaceutical Technology

Autotaxin inhibitors

Novartis

Diazepinone derivatives

Novartis

Pyridone FabI inhibitors and uses thereof

The Research Foundation For The State University of New York

Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors

Merck Sharp & Dohme

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.

Emory University

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

Washington University

Tyrosine kinase inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

University of Auckland