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Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D

National Institute On Drug Abuse-Intramural Research Program

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

National Institute On Drug Abuse-Intramural Research Program

Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.

National Institute On Drug Abuse-Intramural Research Program

Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.

National Institute On Drug Abuse-Intramural Research Program

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

National Institute On Drug Abuse-Intramural Research Program

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

National Institute On Drug Abuse-Intramural Research Program

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.

National Institute On Drug Abuse-Intramural Research Program

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

National Institute On Drug Abuse-Intramural Research Program

Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues.

National Institute On Drug Abuse-Intramural Research Program

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.

National Institute On Drug Abuse-Intramural Research Program

Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.

National Institute On Drug Abuse-Intramural Research Program

N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.

National Institute On Drug Abuse-Intramural Research Program

Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.

National Institute On Drug Abuse-Intramural Research Program

Novel tropane-based irreversible ligands for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.

National Institute On Drug Abuse-Intramural Research Program

Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.

National Institute On Drug Abuse-Intramural Research Program

CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.

National Institute On Drug Abuse-Intramural Research Program

The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.

National Institute On Drug Abuse-Intramural Research Program

[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.

National Institute On Drug Abuse-Intramural Research Program

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

National Institute On Drug Abuse-Intramural Research Program

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

National Institute On Drug Abuse-Intramural Research Program

Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.

National Institute On Drug Abuse-Intramural Research Program

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.

National Institute On Drug Abuse-Intramural Research Program

Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.

National Institute On Drug Abuse-Intramural Research Program

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.

National Institute On Drug Abuse-Intramural Research Program

Novel Dual-Target μ-Opioid Receptor and Dopamine D

National Institute On Drug Abuse-Intramural Research Program

N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.

National Institute On Drug Abuse-Intramural Research Program

Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D

National Institute On Drug Abuse-Intramural Research Program

Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

[3H]MFZ 2-12: a novel radioligand for the dopamine transporter.

National Institute On Drug Abuse-Intramural Research Program

Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.

National Institute On Drug Abuse-Intramural Research Program

Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

National Institute On Drug Abuse-Intramural Research Program

Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D

National Institute On Drug Abuse-Intramural Research Program

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D

National Institute On Drug Abuse-Intramural Research Program

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

National Institute On Drug Abuse-Intramural Research Program

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

National Institute On Drug Abuse-Intramural Research Program

2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.

National Institute On Drug Abuse-Intramural Research Program

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D

National Institute On Drug Abuse-Intramural Research Program

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

National Institute On Drug Abuse-Intramural Research Program