PMID

Data

Article Title

Organization

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Merck Frosst Canada

A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.

Merck Frosst Canada

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.

Merck Frosst Canada

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.

Merck Frosst Canada

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Merck Frosst Canada

Identification of an indole series of prostaglandin D2 receptor antagonists.

Merck Frosst Canada

Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.

Merck Frosst Canada

Structure-based design of COX-2 selectivity into flurbiprofen.

Merck Frosst Canada

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.

Merck Frosst Canada

Tricyclic PI3K inhibitor compounds and methods of use

Genentech

Aminotriazine derivative and pharmaceutical composition comprising the same

Shionogi

Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

Istituto Di Biostrutture E Bioimmagini-Cnr

 

Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties.

Tumor Biology Center