21 articles for thisTarget
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Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.
Latvian Institute of Organic Synthesis
Substrate derived peptidica-ketoamides as inhibitors of the malarial protease PfSUB1.
Latvian Institute of Organic Synthesis
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.
Latvian Institute of Organic Synthesis
Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.
Latvian Institute of Organic Synthesis
Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists.
Latvian Institute of Organic Synthesis
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.
Latvian Institute of Organic Synthesis
Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent
Latvian Institute of Organic Synthesis
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library.
Latvian Institute of Organic Synthesis
Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect.
Latvian Institute of Organic Synthesis
Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery.
Latvian Institute of Organic Synthesis
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
Latvian Institute of Organic Synthesis
Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.
Latvian Institute of Organic Synthesis
Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors.
Latvian Institute of Organic Synthesis
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.
Latvian Institute of Organic Synthesis
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.
Latvian Institute of Organic Synthesis
6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.
Latvian Institute of Organic Synthesis
Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.
Latvian Institute of Organic Synthesis
2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.
Latvian Institute of Organic Synthesis
Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists.
Latvian Institute of Organic Synthesis