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Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.

Kumamoto University

Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.

Kumamoto University

Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.

Kumamoto University

Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.

Kumamoto University

Synthesis and biological evaluation of loxoprofen derivatives.

Kumamoto University

Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.

Kumamoto University

Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.

Kumamoto University

Crystal Structures of Metallo-β-Lactamase (IMP-1) and Its D120E Mutant in Complexes with Citrate and the Inhibitory Effect of the Benzyl Group in Citrate Monobenzyl Ester.

Kumamoto University

Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp.

Kumamoto University

Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.

Kumamoto University

A novel metal-chelating inhibitor of protein farnesyltransferase.

Kumamoto University

New SIRT2 inhibitors: Histidine-based bleomycin spin-off.

Kumamoto University

Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens.

Kumamoto University

Sulawesins A-C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a Psammocinia sp. Marine Sponge.

Kumamoto University