34 articles for thisTarget
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Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

Indiana University School of Medicine
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

Indiana University School of Medicine
Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase.

Indiana University School of Medicine
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.

Indiana University School of Medicine
Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.

Indiana University School of Medicine
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.

Indiana University School of Medicine
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

Indiana University School of Medicine
[11C]olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand.

Indiana University School of Medicine
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Indiana University School of Medicine
Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.

Indiana University School of Medicine
Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

Indiana University School of Medicine
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Indiana University School of Medicine
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.

Indiana University School of Medicine
Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging.

Indiana University School of Medicine
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Indiana University School of Medicine
Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase.

Indiana University School of Medicine
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.

Indiana University School of Medicine
Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.

Indiana University School of Medicine
Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPARĀ·uPA Interaction.

Indiana University School of Medicine
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

Indiana University School of Medicine
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.

Indiana University School of Medicine
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.

Indiana University School of Medicine
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.

Indiana University School of Medicine
Synthesis and in vitro biological evaluation of new P2X7R radioligands [

Indiana University School of Medicine
Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

Indiana University School of Medicine
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Indiana University School of Medicine
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.

Indiana University School of Medicine
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.

Indiana University School of Medicine
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).

Indiana University School of Medicine
Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.

Indiana University School of Medicine
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.

Indiana University School of Medicine
Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

Indiana University School of Medicine