PMID

Data

Article Title

Organization

Optimization of a series of potent and selective ketone histone deacetylase inhibitors.

Irbm/Merck Research Laboratories

A series of novel, potent, and selective histone deacetylase inhibitors.

Irbm/Merck Research Laboratories

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Irbm/Merck Research Laboratories

Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Irbm/Merck Research Laboratories

Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.

Irbm/Merck Research Laboratories

Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.

Irbm/Merck Research Laboratories

Tropomyosin-related kinase (Trk) inhibitors

Genzyme

Substituted triazoles useful as Axl inhibitors

Rigel Pharmaceuticals

Potent and selective nonpeptide inhibitors of caspases 3 and 7.

Glaxosmithkline