Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50028719
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258551((S)-N-hydroxy-7-(2-(5-methoxy-2-methyl-1H-indol-3-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258625((S)-7-(5-(naphthalen-2-yl)-1H-imidazol-2-yl)-7-(2-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258582((S)-7-(5-(naphthalen-2-yl)-1H-imidazol-2-yl)-7-(th...)
Affinity DataIC50: 23nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: 27nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258549((S)-2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-(1-(5-(...)
Affinity DataIC50: 27nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258550((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 28nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 30nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258552((S)-N-methoxy-7-(2-(5-methoxy-2-methyl-1H-indol-3-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258624((S)-7-(1-methylpiperidine-4-carboxamido)-7-(5-(nap...)
Affinity DataIC50: 35nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258584((S)-7-((S)-1-methylpyrrolidine-3-carboxamido)-7-(5...)
Affinity DataIC50: 40nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 43nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 44nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258553((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258627((S)-N-ethyl-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl...)
Affinity DataIC50: 66nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258583((S)-7-((R)-1-methylpyrrolidine-3-carboxamido)-7-(5...)
Affinity DataIC50: 73nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258554((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 94nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258633((S)-N-(2-aminophenyl)-7-(2-(5-methoxy-2-methyl-1H-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258555((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 120nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 120nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258631((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 170nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258630((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258585((S)-7-(N,N-dimethylsulfamoylamino)-7-(5-(naphthale...)
Affinity DataIC50: 220nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258632((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 350nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258628((S)-N-isopropyl-7-(2-(5-methoxy-2-methyl-1H-indol-...)
Affinity DataIC50: 480nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258629((S)-N-benzyl-7-(2-(5-methoxy-2-methyl-1H-indol-3-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal FLAG tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 8(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His-tagged HDAC8 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of His-tagged HDAC8 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258626((S)-7-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed