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Article Title

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The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

Emory University

An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.

Emory University

A novel class of negative allosteric modulators of NMDA receptor function.

Emory University

Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors.

Emory University

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.

Emory University

Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis.

Emory University

Development of second generation EP2 antagonists with high selectivity.

Emory University

Prostanoid receptor EP2 as a therapeutic target.

Emory University

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

Emory University

Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.

Emory University

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.

Emory University

Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.

Emory University

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.

Emory University

Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.

Emory University

Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.

Emory University

Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.

Emory University

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Emory University

Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors.

Emory University

Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.

Emory University

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

Emory University

Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.

Emory University

Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.

Emory University

Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.

Emory University

Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.

Emory University

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Emory University

Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.

Emory University

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.

Emory University

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

Emory University

Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.

Emory University

Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.

Emory University

Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.

Emory University

Discovery of small molecule CXCR4 antagonists.

Emory University

Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.

Emory University

Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 M

Emory University

Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.

Emory University

Amphiphilic glycoconjugates as potential anti-cancer chemotherapeutics.

Emory University

Ribosome-targeting antibiotics and resistance

Emory University

Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.

Emory University

Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.

Emory University

Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.

Emory University

Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.

Emory University

Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.

Emory University

ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.

Emory University

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.

Emory University

Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.

Emory University

Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.

Emory University

Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.

Emory University

Discovery of Dihydropyrrolo[1,2-

Emory University

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.

Emory University

Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors.

Emory University

Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.

Emory University

Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor.

Emory University

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.

Emory University

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor.

Emory University

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase.

Emory University

Discovery and characterization of carbamothioylacrylamides as EP

Emory University

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.

Emory University

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Emory University

Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.

Emory University

Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.

Emory University

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.

Emory University

Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.

Emory University

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.

Emory University

Discovery of

Emory University

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.

Emory University

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.

Emory University

Development of GLUT4-selective antagonists for multiple myeloma therapy.

Emory University

Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.

Emory University

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

Emory University

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Emory University

Compounds useful for treatment of substance use disorder

High Point University

SUBSTITUTED 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE ANALOGS AS MODULATORS OF MELANOMA-ASSOCIATED ANTIGEN 11 UBIQUITIN LIGASE

ST. JUDE CHILDREN''S RESEARCH HOSPITAL, INC.

BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF

Hangzhou Apeloa Medicine Research Institute Co.

Bicyclic amines as CDK2 inhibitors

Incyte

Opioid compounds and uses thereof

Rhodes Technologies

Pyrazoles

Janssen Pharmaceuticals

Imidazole and triazole containing bicyclic compounds as JAK inhibitors

Theravance Biopharma R&D Ip

Heterocyclic compounds and uses thereof

Infinity Pharmaceuticals

Histone deacetylase inhibitors and methods for use thereof

Reaction Biology

Proton pump inhibitors

Takeda Pharmaceutical

Therapeutic compounds and uses thereof

Genetech

Carboxylic acid compound, method for preparation thereof, and use thereof

Inventisbio Shanghai

Method of treating conditions with kinase inhibitors

Allergan

Triazole agonists of the APJ receptor

Amgen

Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication

Viiv Healthcare UK (NO.5)

Quinolone derivatives as fibroblast growth factor receptor inhibitors

Principia Biopharma

Complement pathway modulators and uses thereof

Novartis

Imidazopyridazine derivatives as modulators of the GABAA receptor activity

Pfizer

5-hydroxytryptamine receptor 7 activity modulators and their method of use

Temple University

Compounds as tyrosine kinase modulators

Allergan

Substituted spirocycles

Boehringer Ingelheim International

2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase

Northwestern University

5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use

Cancer Research Technology

Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

Boehringer Ingelheim International

Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes

Takeda Pharmaceutical

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

University of Massachusetts

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

Case Western Reserve University

Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.

Dupont Pharmaceuticals

Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.

Laboratorium FÜR Organische Chemie

Botryllamides: Natural Product Inhibitors of ABCG2.

Saic-Frederick

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Pfizer

N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

Montana State University

Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.

University of Tennessee Health Science Center

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.

University of California San Francisco

Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists.

Boehringer Ingelheim Pharmaceuticals

Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.

Johnson & Johnson Pharmaceutical

Acylguanidines as small-molecule beta-secretase inhibitors.

Wyeth Research

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

Universite De La Mediterranee

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

Merck Research Laboratories