Affinity DataEC50: 1.37E+5nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 3.95E+4nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 8.28E+4nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 1.16E+5nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 9.70E+4nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 1.05E+5nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 3.05E+4nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataEC50: 1.96E+4nMAssay Description:Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 33nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 337nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 850nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human cytoplasmic LeuRS assessed as reduction in protein synthesis measured after 10 mins in presence of [3H]Leu by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret...More data for this Ligand-Target Pair
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 3.88E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
Affinity DataIC50: 4.49E+4nMAssay Description:Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret...More data for this Ligand-Target Pair
Affinity DataIC50: 4.58E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 6.69E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
Affinity DataIC50: 9.66E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
