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TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM47224(US9073917, 2-inventive)
Affinity DataIC50: 1nMAssay Description:The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Ev que, 86600 Celle...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167515(US9073917, 12- comparative)
Affinity DataIC50: 3nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167506(US9073917, 1-inventive)
Affinity DataIC50: 4nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167510(US9073917, 7- comparative)
Affinity DataIC50: 4nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167507(US9073917, 4- comparative)
Affinity DataIC50: 6nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167508(US9073917, 5- comparative)
Affinity DataIC50: 6nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574278(CHEMBL4854144)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167512(US9073917, 11- comparative | US9073917, 9- compara...)
Affinity DataIC50: 8nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167513(US9073917, 10- comparative)
Affinity DataIC50: 9nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167516(US9073917, 13- comparative)
Affinity DataIC50: 10nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167509(US9073917, 6- comparative)
Affinity DataIC50: 13nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM209861(TAK-901 | 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora B/INCENP (unknown origin) pre-incubated for 1 hr followed by FL-PKAtide substrate and ATP additionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged Aurora B//N-terminal GST-tagged INCENP (821-end residues) expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167511(US9073917, 8- comparative)
Affinity DataIC50: 21nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase C/Inner centromere protein(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Aurora-C (35-end residues)/N-terminal GST-tagged INCENP (821-end residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574272(CHEMBL4875416)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574268(CHEMBL4851020)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574269(CHEMBL4857965)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574270(CHEMBL4855657)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574279(CHEMBL4869229)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574274(CHEMBL4860970)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574275(CHEMBL4856439)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM167512(US9073917, 11- comparative | US9073917, 9- compara...)
Affinity DataIC50: 107nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 150nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574277(CHEMBL4871106)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574271(CHEMBL4876446)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467633(CHEMBL4291945)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574276(CHEMBL4846712)
Affinity DataIC50: 233nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574273(CHEMBL4871853)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198044(CHEMBL3903187)
Affinity DataIC50: 830nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50574280(CHEMBL4853030)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198086(CHEMBL3985313)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198082(CHEMBL3904239)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198081(CHEMBL3915550)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198045(CHEMBL3975102)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198080(CHEMBL3932394)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM60452(US9073917, 3-comparative)
Affinity DataIC50: 3.80E+3nMAssay Description:The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Ev que, 86600 Celle...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467663(CHEMBL4285153)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50198079(CHEMBL3924918)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467634(CHEMBL4284904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467637(CHEMBL4287010)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467650(CHEMBL4282883)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467639(CHEMBL4283270)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467671(CHEMBL4278479)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467649(CHEMBL4283403)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
Sanofi

US Patent
LigandPNGBDBM50467642(CHEMBL4280691)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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