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Report error Found 306 for UniProtKB: Q86U44
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  2.00E+3nMAssay Description:Thermal stabilization of recombinant METTL3 (354 to 580 residues) (unknown origin) expressed in HEK293T cells assessed as non-aggregated METTL3-ePL p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  850nMAssay Description:Thermal stabilization of endogenously expressing full length METTL3 in human MOLM-13 cells assessed as stabilized METTL3 incubated for at 54 degC by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM612842(US11725010, Example 1)
Affinity DataIC50: 3.84nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant METLL3 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in N6-methyladenosine level in oli...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM639425(({3- fluorobicyclo[1.1.1] pentan-1- yl}methyl)[(2-...)
Affinity DataIC50: 6nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM639431(3-{1-[(6-{[({3- fluorobicyclo[1.1.1] pentan-1- yl}...)
Affinity DataIC50: 6nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM639432(({3- fluorobicyclo[1.1.1] pentan-1-yl}methyl) ({[2...)
Affinity DataIC50: 6nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM661908((2R,3R,4S,5R)-2- {4-amino-5-bromo- 7H-pyrrolo[2,3-...)
Affinity DataIC50: 6nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM661913(US20240101589, Example 11)
Affinity DataIC50: 6nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612843(US11725010, Example 2 | BDBM613184)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612844(US11725010, Example 3 | N-[[2-[[(3,3- difluorocycl...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612846(US11725010, Example 4 | N-[[2-[[(1- hydroxycyclobu...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612848(US11725010, Example 6)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612858(US11725010, Example 11 | N-[[2-[(1- adamantylamino...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612884(US11725010, Example 15 | N-[[2-[[(1- hydroxycyclo-...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613160(US11725010, Example 23 | N-[(2-{[({3- fluorobicycl...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613163(US11725010, Example 26 | N-[[2- [(cyclopentyl- ami...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613164(US11725010, Example 27 | N-[[2- [(cyclopentyl- met...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613167(US11725010, Example 30 | N-[[2- [(cyclohexylamino)...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613171(US11725010, Example 34 | N-[[2-[(2,2- dimethylprop...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613172(US11725010, Example 35 | N-[[2-[(1- bicyclo[1.1.1]...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613173(US11725010, Example 36 | N-{[2- ({[(1S,2S)-2- hydr...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613175(US11725010, Example 38 | N-{[2- ({[(1S,2R)-2- hydr...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613178(US11725010, Example 41 | N-[[2- [(cyclobutyl- meth...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613182(US11725010, Example 45)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM612843(US11725010, Example 2 | BDBM613184)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613192(US11725010, Example 55 | N-[[6-[[4- (1H-indazol- 4...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613194(US11725010, Example 57 | 1-[[[6-[[4- (1H-indazol- ...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613195(US11725010, Example 58)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613196(US11725010, Example 59)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613197(US11725010, Example 60)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613199(US11725010, Example 62)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613204(US11725010, Example 67 | N-[[2-(2- azaspiro[3.3] h...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613213(US11725010, Example 76 | N-[(2- {[({bicyclo[2.1.1]...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613214(US11725010, Example 77 | N-[(2-{[({3- methylbicycl...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613218(US11725010, Example 81 | N-{[2-({2- azaspiro[3.4] ...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613227(US11725010, Example 90 | N-{[2-({2- azaspiro[3.5] ...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613229(US11725010, Example 122 | 4-(1-{[2-({2- azaspiro[3...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613232(US11725010, Example 92 | N-({2-[(3,3- dimethylpyrr...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613233(US11725010, Example 93 | N-{[2-({6- fluoro-2- azas...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613234(US11725010, Example 94 | N-{[2-({6,6- difluoro-2- ...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613235(US11725010, Example 95 | N-({2-[(3- cyclobutylazet...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613241(US11725010, Example 124)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613243(US11725010, Example 102 | N-({2-[(3,3- diethylazet...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613246(US11725010, Example 114)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613247(US11725010, Example 104 | N-{[2-({6- azaspiro[3.4]...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613248(US11725010, Example 116 | N-[(2-{[(1- cyclobutylcy...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM613250(US11725010, Example 106 | N-{[2- ({octahydro- cycl...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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