Compile Data Set for Download or QSAR
Report error Found 2911 for UniProtKB: Q15022
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  114nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM451038(US10676479, Example 68 | 8-(4-((dimethylamino)meth...)
Affinity DataIC50: 0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50287072(CHEMBL4159112 | US10759787, Example 12 | US1105981...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50287050(CHEMBL4161265)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50287052(CHEMBL4165937)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM451070(US10676479, Example 100 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 0.600nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50287284(CHEMBL4160111)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM451062(US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 0.700nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50287068(CHEMBL4172576 | US10759787, Example 30 | US1105981...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM291686(US9580437, Example 1 | 8-(1,3-Dimethyl-1H-pyrazol-...)
Affinity DataIC50: 0.900nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM291695(US9580437, Example 10 | 3-(5-(((5-fluoro-2,3-dihyd...)
Affinity DataIC50: 1nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291815(US9580437, Example 130 | (5-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 1.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291908(US9580437, Example 223 | 8-(6-((dimethylamino)meth...)
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291925(US9580437, Example 240 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 1.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291824(US9580437, Example 139 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291824(US9580437, Example 139 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.70nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM498166(US11013745, Compound SL-E14)
Affinity DataIC50: 1.70nMAssay Description:The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291814(US9580437, Example 129 | (5-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 1.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291823(US9580437, Example 138 | 8-(4-chloro-6-methoxypyri...)
Affinity DataIC50: 1.90nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 1.90nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291853(US9580437, Example 168 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 2nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291918(US9580437, Example 233 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM450978(US10676479, Example 10 | 1-Chloro-8-(2,4-dimethylp...)
Affinity DataIC50: 2nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 2nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291689(US9580437, Example 4 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 2.10nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 2.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM490331(US10968215, Compound 153)
Affinity DataIC50: 2.15nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291882(US9580437, Example 197 | 8-(6-(difluoromethoxy)-4-...)
Affinity DataIC50: 2.20nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 2.20nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM498165(US11013745, Compound SL-ZYE-183)
Affinity DataIC50: 2.20nMAssay Description:The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291873(US9580437, Example 188 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.30nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM450981(US10676479, Example 13 | 8-(2-(Difluoromethyl)pyri...)
Affinity DataIC50: 2.30nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451053(US10676479, Example 83 | 8-(2-(3,5-dimethylpiperaz...)
Affinity DataIC50: 2.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291827(US9580437, Example 142 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291830(US9580437, Example 145 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291879(US9580437, Example 194 | 8-(2,5-dimethylpyridin-4-...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 2.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451054(US10676479, Example 84 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451072(US10676479, Example 102 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.40nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291867(US9580437, Example 182 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291875(US9580437, Example 190 | 2-(4-(5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 2.5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451056(US10676479, Example 86 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM498157(US11013745, Compound SL-ZYE-147)
Affinity DataIC50: 2.5nMAssay Description:The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 2.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291812(US9580437, Example 127 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM291866(US9580437, Example 181 | 8-(2-(difluoromethyl)-3-m...)
Affinity DataIC50: 2.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM451088(US10676479, Example 118 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.60nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM490276(US10968215, Compound 152)
Affinity DataIC50: 2.65nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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