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TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078572(CHEMBL297496 | {4-[(4-Dimethylamino-phenyl)-(4-{3-...)
Affinity DataKd:  1.20nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
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PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078573(Phosphoric acid 3-amino-propyl ester (1R,2R,3S,4R,...)
Affinity DataKd:  1.12E+3nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataKd:  195nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50078574(inositol 1,4,5-trisphosphate analogue | CHEMBL4627...)
Affinity DataKd:  188nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50279840((L)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-tripho...)
Affinity DataEC50:  210nMAssay Description:Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Ins(1,4,5)P3 receptorMore data for this Ligand-Target Pair
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LigandPNGBDBM50211666(CHEMBL1161456)
Affinity DataEC50:  130nMAssay Description:Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
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LigandPNGBDBM50279840((L)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-tripho...)
Affinity DataEC50:  410nMAssay Description:Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50279840((L)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-tripho...)
Affinity DataEC50:  410nMAssay Description:Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
In DepthDetails Article

TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075651(1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosph...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
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PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075647(Phosphoric acid mono-((1R,2S,3R,4S,5S,6R)-2,3,4-tr...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
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PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075648((1R,3S,4R,6R)-4,5,6-trihydroxy-2-methyl-2,3-bis(ph...)
Affinity DataIC50: 44nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075649(1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosph...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50075650(1L-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosph...)
Affinity DataIC50: 620nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50211666(CHEMBL1161456)
Affinity DataKi:  2.92E+5nMAssay Description:Compound was evaluated for its ability to inhibit Inositol phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article