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Report error Found 15 for UniProtKB: Q13564
TargetNEDD8-activating enzyme E1 catalytic/regulatory subunit(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC803 cells assessed as reduction in Nedd8-Ubcl2 adduct formation incubated for 24 hrs by Western bl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50: 10nMAssay Description:Inhibition of NAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 180nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50574026(CHEMBL4282603)
Affinity DataIC50: 260nMAssay Description:Inhibition of NAE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50427031(CHEMBL2322197)
Affinity DataIC50: 800nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed NEDD8-Ubcl2 intermediate formation by densitometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NAE (unknown origin) assessed as decrease in NEDD8-Ubcl2 formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562350(CHEMBL4788522)
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562351(CHEMBL4746177)
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562352(CHEMBL4744561)
Affinity DataIC50: 9.94E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50318907(CHEMBL1014 | TCV-116 | candesartancilexetil | Atac...)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed transthiolation of NEDD8 from NAE to Ubc12More data for this Ligand-Target Pair
In DepthDetails Article
PubMed