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TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50241990(CHEMBL502489 | Camboginol | Garcinol, 1 | Garcinol)
Affinity DataKd:  400nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM84873(Nemorosone, 2)
Affinity DataKd:  250nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM84874(Guttiferone A, 3)
Affinity DataKd:  100nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM84875(Guttiferone E, 4)
Affinity DataKd:  390nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM84877(Clusianone, 10)
Affinity DataKd:  810nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50081171(CHEMBL3421905)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to human recombinant P300 catalytic domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50081172(CHEMBL3421930)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant P300 catalytic domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  32nMAssay Description:Binding affinity to human p300 by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  167nMAssay Description:Inhibition of human p300 expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataKd:  345nMAssay Description:Binding affinity to recombinant P300 CH1 domain assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50241990(CHEMBL502489 | Camboginol | Garcinol, 1 | Garcinol)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by fluorometric titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50265449((1R,3S,9S,11R)-7-(3-Hydroxy-4-methoxy-benzoyl)-4,4...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by fluorometric titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50377962(CAMBOGIN)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by fluorometric titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50241990(CHEMBL502489 | Camboginol | Garcinol, 1 | Garcinol)
Affinity DataKd:  6.60E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50265449((1R,3S,9S,11R)-7-(3-Hydroxy-4-methoxy-benzoyl)-4,4...)
Affinity DataKd:  9.10E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50377962(CAMBOGIN)
Affinity DataKd:  5.90E+3nMAssay Description:Binding affinity to HAT p300 catalytic domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50198751(CHEMBL3927642)
Affinity DataKd:  134nMAssay Description:Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  151nMAssay Description:Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  21nMAssay Description:Binding affinity to human N-terminal His10-tagged/C-terminal Biotin-tagged CBP (R1081 to G1198 residues)/P300 expressed in Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataEC50:  69nMAssay Description:Inhibition of CBP/EP300 in human MOLM16 cells assessed as decrease in MYC expression measured after 4 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataEC50:  6.60E+3nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM50151661(CHEMBL3752296)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataEC50:  910nMAssay Description:Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM220447(US9296741, 36 | US10633379, Compound X)
Affinity DataKd:  87nMAssay Description:Binding affinity to human EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd:  110nMAssay Description:Binding affinity to human EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged EP300 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd:  550nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453948(CHEMBL4204490 | US11247989, Example 96)
Affinity DataEC50:  76nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataEC50:  32nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453970(CHEMBL4207965 | US11247989, Example 98)
Affinity DataEC50:  110nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453971(CHEMBL4204065 | US11247989, Example 11)
Affinity DataEC50:  280nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataEC50:  18nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453957(CHEMBL4217213)
Affinity DataEC50:  6.60nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453976(CHEMBL4209361 | US11247989, Example 97)
Affinity DataEC50:  220nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)
Affinity DataEC50:  53nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250911(CHEMBL4095153 | US10696655, Example 45 | US1116807...)
Affinity DataEC50:  12nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250913(CHEMBL4073812 | US10696655, Example 67 | US1116807...)
Affinity DataEC50:  360nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50537291(CHEMBL4555191)
Affinity DataKd:  750nMAssay Description:Binding affinity to human GST-fused p300 CH1 domain (323 to 423 residues) under hypoxic condition by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50524839(CHEMBL4466328)
Affinity DataKd:  530nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50537293(CHEMBL4590644)
Affinity DataKd:  6.74E+3nMAssay Description:Binding affinity to p300 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50537294(CHEMBL4514946)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50537295(CHEMBL4524475)
Affinity DataKd:  690nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50524834(CHEMBL4435255)
Affinity DataKd:  690nMAssay Description:Binding affinity to p300 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Universitá

LigandPNGBDBM50524839(CHEMBL4466328)
Affinity DataKd:  530nMAssay Description:Binding affinity to p300-CH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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