Compile Data Set for Download or QSAR
Report error Found 84 for UniProtKB: Q09428
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  200nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210320([(2Z)-4-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]...)
Affinity DataEC50:  2.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210319(4-amino-6-methoxy-2-(trifluoromethyl)quinoline-3-c...)
Affinity DataEC50:  1.50E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210318(6-chloro-4-hydroxy-2-oxo-N-1,3-thiazol-2-yl-2H-chr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
University of Mainz

Curated by ChEMBL
LigandPNGBDBM50153522(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Affinity DataKd:  134nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
University of Mainz

Curated by ChEMBL
LigandPNGBDBM50025847(CHEMBL3330879)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
University of Mainz

Curated by ChEMBL
LigandPNGBDBM50025834(CHEMBL3330880)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
University of Mainz

Curated by ChEMBL
LigandPNGBDBM50153521(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Affinity DataKd:  83nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
University of Mainz

Curated by ChEMBL
LigandPNGBDBM50153520(CHEMBL1272 | AGEE-623ZW | 2-Ethoxy-4-{[(S)-3-methy...)
Affinity DataKd:  50nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  400nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  196nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119270(Cyclobutyl-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo...)
Affinity DataEC50:  1.96E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119271(Cyclobutyl-(7-methoxy-1,1-dioxo-1,4-dihydro-1lambd...)
Affinity DataEC50:  3.87E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119273(N*3*-Cyclobutyl-1,1-dioxo-1,4-dihydro-1lambda*6*-b...)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119274(Cyclobutyl-(7-nitro-1,1-dioxo-1,4-dihydro-1lambda*...)
Affinity DataEC50:  530nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119270(Cyclobutyl-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo...)
Affinity DataEC50:  2.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119273(N*3*-Cyclobutyl-1,1-dioxo-1,4-dihydro-1lambda*6*-b...)
Affinity DataEC50:  3.20E+4nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  356nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378565(CHEMBL568795)
Affinity DataEC50:  80nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139704(3-(2,4-Difluoro-phenyl)-4-nitro-5-trifluoromethyl-...)
Affinity DataEC50:  1.15E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139706(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Affinity DataEC50:  70nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139707(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-isoxa...)
Affinity DataEC50: >3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139709(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Affinity DataEC50:  540nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139710(4-Nitro-3-phenyl-5-trifluoromethyl-1H-pyrazole | C...)
Affinity DataEC50:  3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139708(3-(4-Nitro-phenyl)-5-trifluoromethyl-1H-pyrazole |...)
Affinity DataEC50: >3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139705(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Affinity DataEC50:  700nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50119271(Cyclobutyl-(7-methoxy-1,1-dioxo-1,4-dihydro-1lambd...)
Affinity DataEC50:  4.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM56470(2-(2-imino-3-methyl-1-benzimidazolyl)-1-thiophen-2...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210325(3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboni...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210323(2-{[(4-chlorophenyl)sulfonyl]amino}benzamide | CHE...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210324(6-phenylpteridin-4(3H)-one | CHEMBL228035)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210322(N-[1-(2-pyrrolidin-1-ylethyl)-1H-benzimidazol-2-yl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50130735((7-chloro-1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadi...)
Affinity DataEC50:  250nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50210321(5-methoxy-2-piperidin-1-yl-1H-benzimidazole | CHEM...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190501(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)
Affinity DataEC50:  530nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataEC50:  180nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190496(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)
Affinity DataEC50:  810nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190502(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)
Affinity DataEC50:  160nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  3.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50118351(6-chloro-3-(1-methylcyclobutyl)-amino-4H-thieno[3,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataIC50: 81nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 84 total ) | Next | Last >>
Jump to: