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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560698(US11389438, # 1)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560699(US11389438, # 2)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560700(US11389438, # 3)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560701(US11389438, # 11)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560702(US11389438, # 20)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560703(US11389438, # 21)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560705(US11389438, # 22)
Affinity DataKd:  300nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560706(US11389438, # 23)
Affinity DataKd:  300nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560707(US11389438, # 24)
Affinity DataKd:  300nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560709(US11389438, # 25)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560710(US11389438, # 26)
Affinity DataKd:  300nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560711(US11389438, # 43)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560712(US11389438, # 44)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560809(US11389438, # 45)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560810(US11389438, # 46)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560811(US11389438, # 47)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560812(US11389438, # 48)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560813(US11389438, # 53)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560814(US11389438, # 54)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560815(US11389438, # 55)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560816(US11389438, # 56)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560817(US11389438, # 57)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560818(US11389438, # 58)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
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TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677285(US20240174649, Compound 33)
Affinity DataKd:  1.84E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677286(US20240174649, Compound 33-2)
Affinity DataKd:  1.50E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677287(US20240174649, Compound 33-3)
Affinity DataKd: >5.00E+5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677288(US20240174649, Compound 33-4)
Affinity DataKd:  1.90E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677289(US20240174649, Compound 33-5)
Affinity DataKd:  4.80E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677290(US20240174649, Compound 33-7)
Affinity DataKd:  5.70E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677291(US20240174649, Compound KH-4-43)
Affinity DataKd:  550nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677292(US20240174649, Compound #33-11)
Affinity DataKd:  1.59E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677293(US20240174649, Compound KH-3-115)
Affinity DataKd:  3.77E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677294(US20240174649, Compound MM-007)
Affinity DataKd:  3.80E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677295(US20240174649, Compound MM-008)
Affinity DataKd:  2.64E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-1(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677296(US20240174649, Compound MM-009)
Affinity DataKd: >4.00E+5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677297(US20240174649, Example Table9.1)
Affinity DataKd:  1.89E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677298(US20240174649, Example Table9.2)
Affinity DataKd:  1.42E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677299(US20240174649, Example Table9.3)
Affinity DataKd:  1.90E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677300(US20240174649, Example Table9.4)
Affinity DataKd:  1.95E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase RBX1/Cullin-4A(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM677301(US20240174649, Example Table9.5)
Affinity DataKd:  1.19E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454848(US10730870, Example 11 | US11512083, Example 11)
Affinity DataIC50: 16.3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
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TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454972(US10730870, Example 141 | US11512083, Example 141)
Affinity DataIC50: 70.9nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
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TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataIC50: 100nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454909(US10730870, Example 76 | US11512083, Example 76)
Affinity DataIC50: 169nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454884(US10730870, Example 47 | US11512083, Example 47)
Affinity DataIC50: 178nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454907(US10730870, Example 74 | US11512083, Example 74)
Affinity DataIC50: 264nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454853(US10730870, Example 16 | US11512083, Example 16)
Affinity DataIC50: 265nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454897(US10730870, Example 60 | US11512083, Example 60)
Affinity DataIC50: 293nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454846(US10730870, Example 9 | US11512083, Example 9)
Affinity DataIC50: 309nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454854(US10730870, Example 17 | US11512083, Example 17)
Affinity DataIC50: 317nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

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