Compile Data Set for Download or QSAR
Report error Found 566 for UniProtKB: P49810
LigandPNGBDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50: 0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185414((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185405((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185413((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185408((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50171224(Cyclic sulfamide | CHEMBL196215)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185406((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185412((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPresenilin-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393452(CHEMBL2159511)
Affinity DataIC50: 1nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50223758(CHEMBL58925)
Affinity DataIC50: 1nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50171213(Cyclic sulfamide | CHEMBL194788)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185409((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50: 1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185403((+/-)-(4aS,6R,8aS)-3-tert-butyl-6-(4-chloro-benzen...)
Affinity DataIC50: 1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPresenilin-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393453(CHEMBL2159510)
Affinity DataIC50: 2nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50171219(Cyclic sulfamide | CHEMBL198301)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50189039(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPresenilin-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)
Affinity DataIC50: 3nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPresenilin-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)
Affinity DataIC50: 3nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50166702(2-[1-(4-Chloro-benzenesulfonyl)-cyclohexyl]-1,4-di...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of gamma-secretase as amyloid peptide production in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50186575(cis-methyl 4-(3-(4-chlorophenylsulfonyl)-3-(2,5-di...)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129269(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129269(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50171215(Cyclic sulfamide | CHEMBL198302)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)
Affinity DataIC50: 3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50223748(CHEMBL406322)
Affinity DataIC50: 4nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50171223(Cyclic sulfamide | CHEMBL195551)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50593495(CHEMBL5196156)
Affinity DataIC50: 4.5nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)
Affinity DataIC50: 4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50223752(CHEMBL117978)
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50036330(CHEMBL3353090)
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50223740(CHEMBL431679)
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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