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Report error Found 279 of affinity data for UniProtKB/TrEMBL: P48449
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271528(rac-N-(4-(hydroxy(phenyl)methyl)phenethyl)-4-cyano...)
Affinity DataEC50:  100nMAssay Description:Inhibition of 2,3-oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50055641(3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl...)
Affinity DataIC50: 0.220nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130785(CHEMBL609978 | CHEMBL542453 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130785(CHEMBL609978 | CHEMBL542453 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50055642(2,2-Dimethyl-3-[(3E,7E,11E)-3,7,12-trimethyl-15-(4...)
Affinity DataIC50: 2.30nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.88nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128060({4-[4-(Allyl-methyl-amino)-but-2-enyloxy]-phenyl}-...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271572(1-[4-Chlorophenylcarbonyl]-4-[4-(pyridin-4-yl)phen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 2,3-oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.47nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.07nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130788(CHEMBL611484 | CHEMBL116705 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130788(CHEMBL611484 | CHEMBL116705 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50: 4.30nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Trypanosoma bruceiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50: 4.60nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130783(CHEMBL115020 | CHEMBL611485 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130783(CHEMBL115020 | CHEMBL611485 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255431(4-(trifluoromethyl)phenyl 4-(5-(allyl(methyl)amino...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.37nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130789(Allyl-{6-[3-(4-bromo-phenyl)-benzo[b]thiophen-6-yl...)
Affinity DataIC50: 5.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271622(1-[4-Chlorophenylsulfonyl]-4-[4-(4-methylpiperazin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of 2,3-oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130786(CHEMBL611486 | CHEMBL115923 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.20nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130786(CHEMBL611486 | CHEMBL115923 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130774(CHEMBL611757 | CHEMBL115375 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130774(CHEMBL611757 | CHEMBL115375 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128072({4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CY...)
Affinity DataIC50: 6.46nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130775(CHEMBL554209 | CHEMBL611758 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.70nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130775(CHEMBL554209 | CHEMBL611758 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130772(Allyl-{6-[3-(4-bromo-phenyl)-1,1-dioxo-1H-1lambda*...)
Affinity DataIC50: 7.80nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50394835(CHEMBL2164235)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423108(CHEMBL612024)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130784(Allyl-{6-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinol...)
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol synthase(Human)
Laboratoire Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130784(Allyl-{6-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinol...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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