Compile Data Set for Download or QSAR
Report error Found 49 of affinity data for UniProtKB/TrEMBL: P48442
LigandPNGBDBM50139126(CHEMBL3753320)
Affinity DataEC50:  132nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50404271(CHEMBL2092942)
Affinity DataEC50:  132nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140175(CHEMBL3753729)
Affinity DataEC50:  136nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140173(CHEMBL3753306)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140170(CHEMBL3754639)
Affinity DataEC50:  102nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139127(CHEMBL3753595)
Affinity DataEC50:  112nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139126(CHEMBL3753320)
Affinity DataEC50:  131nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50404271(CHEMBL2092942)
Affinity DataEC50:  132nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140175(CHEMBL3753729)
Affinity DataEC50:  135nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140173(CHEMBL3753306)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140170(CHEMBL3754639)
Affinity DataEC50:  102nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50139127(CHEMBL3753595)
Affinity DataEC50:  112nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50147700((1H-Indol-2-ylmethyl)-(1-naphthalen-1-yl-ethyl)-am...)
Affinity DataEC50:  1.30E+3nMAssay Description:Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50404271(CHEMBL2092942)
Affinity DataEC50:  1.00E+3nMAssay Description:Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261661(CHEMBL4071600)
Affinity DataEC50:  316nMAssay Description:Agonist activity at rat CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272596(CHEMBL4126450)
Affinity DataIC50: 0.470nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272602(CHEMBL4126877)
Affinity DataIC50: 0.910nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272605(CHEMBL4128542)
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272606(CHEMBL4125917)
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272607(CHEMBL4126057)
Affinity DataIC50: 4.30nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272604(CHEMBL4129011)
Affinity DataIC50: 7.80nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261663(CHEMBL4079960)
Affinity DataIC50: 8nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272608(CHEMBL4125688)
Affinity DataIC50: 9.70nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272592(CHEMBL4125724)
Affinity DataIC50: 12nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272595(CHEMBL4127153)
Affinity DataIC50: 13nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272591(CHEMBL4128835)
Affinity DataIC50: 31nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272594(CHEMBL4130093)
Affinity DataIC50: 32nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272603(CHEMBL4130141)
Affinity DataIC50: 100nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272593(CHEMBL4129371)
Affinity DataIC50: 116nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193410(N-[(1S,2S)-2-((R)-1-naphthalen-1-yl-ethylamino)-cy...)
Affinity DataIC50: 250nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50346036(Ronacaleret | CHEMBL1198855)
Affinity DataIC50: 320nMAssay Description:Negative allosteric modulator activity at rat calcium sensing receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193411(3,4-dichloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)...)
Affinity DataIC50: 330nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 460nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 530nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50193408(N-((1R,2R)-2-((R)-1-(naphthalen-1-yl)ethylamino)cy...)
Affinity DataIC50: 900nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193408(N-((1R,2R)-2-((R)-1-(naphthalen-1-yl)ethylamino)cy...)
Affinity DataIC50: 1.70E+3nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175371(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50175365(2-fluoro-6-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(n...)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193412(N-[(1S,2S)-2-((R)-1-naphthalen-1-yl-ethylamino)-cy...)
Affinity DataIC50: 2.60E+3nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193407(N1-[4-(trifluoromethoxy)benzenesulfonyl)-N2-[1-(1-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193413(4-methoxy-N-((1R,2R)-2-(1-(naphthalen-1-yl)ethylam...)
Affinity DataIC50: 8.00E+3nMAssay Description:Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133682(CHEMBL3633656)
Affinity DataIC50: 5.62E+4nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133682(CHEMBL3633656)
Affinity DataIC50: 5.62E+4nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133685(CHEMBL3633663)
Affinity DataIC50: 2.40E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133685(CHEMBL3633663)
Affinity DataIC50: 2.40E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133676(CHEMBL3633650)
Affinity DataIC50: 3.16E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133676(CHEMBL3633650)
Affinity DataIC50: 3.16E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133679(CHEMBL3633665)
Affinity DataIC50: 3.47E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133679(CHEMBL3633665)
Affinity DataIC50: 3.47E+5nMAssay Description:Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed