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Report error Found 564 of affinity data for UniProtKB/TrEMBL: P35610
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466752(CHEMBL4281138)
Affinity DataIC50: 3nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182852(US9149492, Compound 1D)
Affinity DataIC50: 3.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182851(US9149492, Compound 1C)
Affinity DataIC50: 3.60nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182849(US9149492, Compound 1A)
Affinity DataIC50: 4.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50462683(CHEMBL4247249)
Affinity DataIC50: 7nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466740(CHEMBL4282905)
Affinity DataIC50: 9nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human SOAT1 expressed in mouse AC29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051894(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182850(US9149492, Compound 1B)
Affinity DataIC50: 10.3nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50360307(CHEMBL449307)
Affinity DataIC50: 20nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(CHEMBL101309 | [2-(2,4,6-Triisopropyl-phenyl)-acet...)
Affinity DataIC50: 25nMAssay Description:Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50: 26nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276562(CHEMBL574414 | CHEMBL449832 | 1-(4-amino-2,6-diiso...)
Affinity DataIC50: 32nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276493(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Affinity DataIC50: 32nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50436124(CHEMBL2397474)
Affinity DataIC50: 32nMAssay Description:Inhibition of macrophage ACAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50: 35nMAssay Description:Compound was tested for inhibitory activity against ACAT from U937 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276483(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 35nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from human liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50: 36nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine adrenal glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50: 36nMAssay Description:Compound was tested for inhibitory activity against ACAT from HepG2 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276487(CHEMBL576152 | CHEMBL500498 | 1-(4-amino-2,6-diiso...)
Affinity DataIC50: 37nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182848(US9149492, Eflucimibe (F12511))
Affinity DataIC50: 39nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276485(CHEMBL574486 | CHEMBL449977 | 1-(4-amino-2,6-diiso...)
Affinity DataIC50: 40nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50360306(CHEMBL505016)
Affinity DataIC50: 40nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50028866(N-[(1S,2R)-2-(4-Hydroxy-phenyl)-indan-1-yl]-2,2-di...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 40nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50: 43nMAssay Description:Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276494(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...)
Affinity DataIC50: 43nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 43nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276484(1-(2,6-diisopropylphenyl)-3-((1-(2-methoxyphenyl)-...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276565(CHEMBL503766 | 1-(4-amino-2,6-diisopropylphenyl)-3...)
Affinity DataIC50: 48nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276488(CHEMBL442567 | CHEMBL572410 | 1-(4-amino-2,6-diiso...)
Affinity DataIC50: 48nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276563(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Affinity DataIC50: 49nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051888({4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051898(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 53nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50089627(Acetic acid 3-acetoxy-4-acetoxymethyl-12-hydroxy-4...)
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051883(1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol acyltransferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051890(2-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50612269(CHEMBL5284960)
Affinity DataIC50: 60nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 62nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset adrenalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50284874(1-(2,6-Diisopropyl-phenyl)-3-((4R,5R)-4,5-dimethyl...)
Affinity DataIC50: 63nMAssay Description:Inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) in microsomes from monkey liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276564(CHEMBL509834 | 1-(4-amino-2,6-diisopropylphenyl)-3...)
Affinity DataIC50: 68nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 69nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset gutMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051891(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol acyltransferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051904(4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50612270(CHEMBL5275490)
Affinity DataIC50: 70nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051884(Diphenylimidazole analogue | 1-[5-(4,5-Diphenyl-1H...)
Affinity DataIC50: 75nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:cholesterol acyltransfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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