Compile Data Set for Download or QSAR
Report error Found 343 of affinity data for UniProtKB/TrEMBL: P31390
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 0.00300nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM31005(MIANSERIN HYDROCHLORIDE | SMR000058472 | MLS000069...)
Affinity DataIC50: 0.00600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50020712(CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...)
Affinity DataIC50: 0.0200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 0.0500nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 0.0600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 0.200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 0.800nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataIC50: 1.07nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataIC50: 2.20nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 5.75nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 23nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 23nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-...)
Affinity DataIC50: 40nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 47nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061559(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 47nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 80nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50002338(10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsul...)
Affinity DataIC50: 99nMAssay Description:Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50162859(2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid {1...)
Affinity DataIC50: 100nMAssay Description:Concentration for 50% inhibition towards central histamine H1 receptor More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50078062(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 120nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50062614(Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine ...)
Affinity DataIC50: 162nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 720nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061560(Trifluoro-methanesulfonic acid 11-(4-methyl-pipera...)
Affinity DataIC50: 720nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202938((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202941((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202947((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202933((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202930((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202926((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202929((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202934((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202924((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203993((+/-)-1-[2-(4-fluorophenyl)-2-(1-isopropylpiperidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203996((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203995((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203994((+/-)-1-[3-(30-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203991((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203992((+/-)-1-[3-(40-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM67545(cid_5887 | PROMAZINE | SR-01000000228-4 | N,N-dime...)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50062598(1-Cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-o...)
Affinity DataIC50: 6.76E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGibogaine(CHEMBL1215855)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 1.26E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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