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Report error Found 363 for UniProtKB: P28565
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM84737(CAS_127792-75-0 | CP-93129 | CHEMBL304008 | 3-(1,2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of rat substantia nigraMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039566((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039567([3-(1-Methyl-pyrrolidin-3-yl)-1H-indol-5-yl]-(3-ni...)
Affinity DataEC50:  2nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039565([3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-(3-nitro...)
Affinity DataEC50:  2nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039564([3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol-5...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataEC50:  97nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280830(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 0.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280826(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280822(4-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 1.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50047098(RP-68303 | 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280819(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 1.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280831(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 1.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280817(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 2.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50016966(CHEMBL543967 | 1,1-Dioxo-2-[4-(4-thieno[3,2-c]pyri...)
Affinity DataIC50: 2.30nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280828(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 2.60nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 3nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227493(CHEMBL288111)
Affinity DataIC50: 3nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039564([3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol-5...)
Affinity DataIC50: 3.10nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280824(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 3.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50016967(CHEMBL544203 | 3-{4-[4-(2-Methyl-thieno[3,2-c]pyri...)
Affinity DataIC50: 3.60nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016957(CHEMBL558026 | 3-[4-(4-Thieno[2,3-c]pyridin-7-yl-p...)
Affinity DataIC50: 3.70nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016956(CHEMBL552616 | 1-{4-[4-(2-Bromo-thieno[3,2-c]pyrid...)
Affinity DataIC50: 3.70nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280823(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 3.70nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50016958(CHEMBL15560 | 1-(4-Fluoro-phenyl)-4-(4-thieno[3,2-...)
Affinity DataIC50: 3.80nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280832(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 3.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280827(1'-{2-[4-(5-fluoro-1H-3-indolylmethyl)hexahydro-1-...)
Affinity DataIC50: 4nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50227485(CHEMBL291097)
Affinity DataIC50: 5nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016963(CHEMBL554473 | 2-[4-(4-Thieno[3,2-c]pyridin-4-yl-p...)
Affinity DataIC50: 5.30nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280829(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 5.40nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50016960(CHEMBL537702 | 4,4-Dimethyl-1-[4-(4-thieno[3,2-c]p...)
Affinity DataIC50: 5.70nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280825(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 5.90nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50280815(N-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 6nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039566((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...)
Affinity DataIC50: 6.20nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227483(CHEMBL36379)
Affinity DataIC50: 8nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016964(CHEMBL537707 | 3-[4-(4-Thieno[3,2-c]pyridin-4-yl-p...)
Affinity DataIC50: 8.10nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016959(CHEMBL537924 | 4-Methyl-1-[4-(4-thieno[3,2-c]pyrid...)
Affinity DataIC50: 8.80nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039565([3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-(3-nitro...)
Affinity DataIC50: 10nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280818(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 12nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 13nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50280821(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 14nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 1D(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039567([3-(1-Methyl-pyrrolidin-3-yl)-1H-indol-5-yl]-(3-ni...)
Affinity DataIC50: 15nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50016479(CHEMBL160976 | LYSERGOL | CHEMBL39947 | cid_14987 ...)
Affinity DataIC50: 15nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 15nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50227484(CHEMBL37867)
Affinity DataIC50: 17nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for the inhibition of [3H]5-HT (concentration of 12 nM) specific binding to rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227482(CHEMBL285723)
Affinity DataIC50: 20nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227486(CHEMBL289517)
Affinity DataIC50: 20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227496(CHEMBL39604)
Affinity DataIC50: 20nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227497(CHEMBL291044)
Affinity DataIC50: 20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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