Compile Data Set for Download or QSAR
Report error Found 287 of affinity data for UniProtKB/TrEMBL: P19490
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.25E+4nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50159745(CHEMBL3786901)
Affinity DataEC50:  1.95E+4nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flop isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50159745(CHEMBL3786901)
Affinity DataEC50:  2.51E+4nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flop isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataEC50:  5.30E+4nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  2.30E+4nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002368((S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PRO...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002368((S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PRO...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at rat recombinant GluA1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  6.40E+3nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  5.10E+4nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataEC50:  8.70E+3nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50128264((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataEC50:  8.28E+4nMAssay Description:Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataEC50:  1.92E+4nMAssay Description:Potency on Ionotropic glutamate receptor AMPA in hippocampal neuronsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50373179(CHEMBL260327)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  3.50E+4nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50373181(CHEMBL406621)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50373180(CHEMBL260328)
Affinity DataEC50:  1.20E+5nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50373182(CHEMBL260122)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50060636(2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMI...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataEC50:  3.36E+4nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50107595(2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclope...)
Affinity DataEC50:  2.49E+4nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataEC50:  1.18E+4nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataEC50:  7.20E+3nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17661((2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimi...)
Affinity DataEC50:  1.15E+4nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataEC50:  380nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  5.10E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  7.00E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126763((S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl...)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295042((S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro...)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  2.30E+4nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50126763((S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl...)
Affinity DataEC50:  7.30E+5nMAssay Description:Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50458948(CHEMBL4204422)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat GluA1 flip isoform expressed in Xenopus laevis oocytes assessed as inhibition of L-Glu-evoked currents under dark condition at -80 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50018845(CHEMBL3286869)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50018846(CHEMBL3286871)
Affinity DataIC50: 15nMAssay Description:Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425996(CHEMBL2314718)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50426005(CHEMBL2314933)
Affinity DataIC50: 19nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399431(CHEMBL2178919)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425988(CHEMBL2314712)
Affinity DataIC50: 28nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425995(CHEMBL2314717)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataIC50: 40nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425997(CHEMBL2314719)
Affinity DataIC50: 43nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50426007(CHEMBL2314935)
Affinity DataIC50: 46nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399430(CHEMBL2178920)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50018844(CHEMBL3286866)
Affinity DataIC50: 52nMAssay Description:Inhibition of rat recombinant GluA1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced channel current at holding potential of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425989(CHEMBL2314713)
Affinity DataIC50: 52nMAssay Description:Inhibition of rat GluA1 receptor flip form expressed in Xenopus laevis oocyte assessed as glutamate-induced current at holding potentials from -80 to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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