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Report error Found 124 of affinity data for UniProtKB/TrEMBL: P16638
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50: 283nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50: 283nMAssay Description:Inhibition of Wistar rat liver ATP citrate lyase using tripotassium citrate as substrate by malate dehydrogenase-based oxaloacetate reduction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50: 283nMAssay Description:Inhibition of rat liver ACLY by MDH enzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50: 283nMAssay Description:Inhibition of rat liver ACLY incubated for 15 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469147(CHEMBL4281691)
Affinity DataIC50: 6.18E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394675(PURPURONE)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469153(CHEMBL4292319)
Affinity DataIC50: 9.63E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Reversible binding potential for rat ATP-Citrate Lyase as carbon-carbon bond cleavage activity in citrate substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity was tested against rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity was tested against rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394678(CHEMBL2165261)
Affinity DataKi:  700nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of rat ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50624088(CHEMBL5438623)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to rat ACLY assessed as inhibition constant measured after 20 minsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053000(2-[8-(2,4-Dichloro-phenyl)-2-oxo-octyl]-2-hydroxy-...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066684((S)-2-[8-(2,4-Dichloro-phenyl)-2-oxo-octyl]-2-hydr...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity was tested against rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053000(2-[8-(2,4-Dichloro-phenyl)-2-oxo-octyl]-2-hydroxy-...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053001(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-su...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053001(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-su...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052989(2-[8-(2,4-Dichloro-phenyl)-octyl]-2-hydroxy-succin...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052995(2-{2-[5-(2,4-Dichloro-phenyl)-pentylsulfanyl]-ethy...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066697((S)-2-[8-(2,4-Dichloro-phenyl)-octyl]-2-hydroxy-su...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity was tested against ATP-Citrate Lyase (ACL) enzyme in ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052989(2-[8-(2,4-Dichloro-phenyl)-octyl]-2-hydroxy-succin...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50018569(CHEMBL63829 | 3,3,14,14-Tetramethyl-hexadecanedioi...)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using CoA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053020(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-2-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of recombinant ATP-Citrate Lyase activity as maleate dehydrogenase catalyzed reduction of oxaloacetate by NADHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053020(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-2-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469149(CHEMBL4283629)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469150(CHEMBL4287406)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469151(CHEMBL4280177)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469152(CHEMBL4290816)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469150(CHEMBL4287406)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity to rat liver ACLY assessed as inhibition constant measured after 15 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50469152(CHEMBL4290816)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity to rat liver ACLY assessed as inhibition constant measured after 15 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052985(2-[5-(2,4-Dichloro-phenyl)-pentylsulfanylmethyl]-2...)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibition of recombinant ATP-Citrate Lyase activity as maleate dehydrogenase catalyzed reduction of oxaloacetate by NADHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361(CHEMBL414883 | Monorden | (4R,6R,8R,9Z,11E)-16-chl...)
Affinity DataKi:  7.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using ATP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  7.00E+3nMAssay Description:Non-competitive inhibition of rat liver ACLY using citrate substrate and varying levels of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to rat ACLY assessed as inhibition constant measured after 20 minsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053010(2-[7-(2,4-Dichloro-phenyl)-heptylsulfanylmethyl]-2...)
Affinity DataKi:  7.20E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052980(2-[6-(2,3-Dichloro-phenyl)-hexylsulfanylmethyl]-2-...)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053016(2-[(E)-6-(2,4-Dichloro-phenyl)-hex-5-enylsulfanylm...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity to rat liver ACLY assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053018(2-[5-(2,4-Dichloro-phenylsulfanyl)-pentylsulfanylm...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053029(2-[6-(3,5-Dichloro-biphenyl-2-yl)-hexylsulfanylmet...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of recombinant ATP-Citrate Lyase activity as maleate dehydrogenase catalyzed reduction of oxaloacetate by NADHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50053027(2-[7-(2,4-Dichloro-phenyl)-heptyl]-2-hydroxy-succi...)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066696((2S,3S)-2-Amino-3-carboxy-3-hydroxy-pentanedioic a...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibitory activity was tested against ATP-Citrate Lyase (ACL) enzyme in ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50052991(2-[5-(2,4-Dichloro-phenylamino)-pentylsulfanylmeth...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361(CHEMBL414883 | Monorden | (4R,6R,8R,9Z,11E)-16-chl...)
Affinity DataKi:  1.30E+4nMAssay Description:Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  1.30E+4nMAssay Description:Non-competitive inhibition of rat liver ACLY using varying levels of citrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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