Affinity DataAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
Affinity DataAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
Affinity DataKd: 1.42nMpH: 7.4 T: 2°CAssay Description:.(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th...More data for this Ligand-Target Pair
Affinity DataKd: 28.5nMpH: 7.4 T: 2°CAssay Description:.(R)- and (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was tested in a radioligand binding assay, according to th...More data for this Ligand-Target Pair
Affinity DataEC50: 0nMAssay Description:AE maximal score at Adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 7.94E+5nMAssay Description:AE maximal score at Adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+7nMAssay Description:AE maximal score at Adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataKd: 0.820nMAssay Description:Binding affinity against human Adenosine A3 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 8.10nMAssay Description:Inhibition of isoproterenol-induced increase of cAMP in HEK293 cell expressing human adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 453nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human adenosine A3 receptor after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.80nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 11.2nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Antagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 36.3nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cA...More data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP release by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 151nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 240nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 320nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 363nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 m...More data for this Ligand-Target Pair
Affinity DataEC50: 4.20nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production tre...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production tre...More data for this Ligand-Target Pair
Affinity DataEC50: 139nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.64E+3nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.52E+3nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.20nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 449nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 776nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
