Compile Data Set for Download or QSAR
Report error Found 34 of affinity data for UniProtKB/TrEMBL: P0A9P4
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627115(CHEMBL5395264)
Affinity DataIC50: 500nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627120(CHEMBL5416840)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627118(CHEMBL5440854)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627116(CHEMBL5397149)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106943(US8592468, EbSe10 | acs.jmedchem.1c00409_ST.159)
Affinity DataIC50: 1.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627119(CHEMBL5429695)
Affinity DataIC50: 2.10E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627112(CHEMBL5429363)
Affinity DataIC50: 3.00E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627114(CHEMBL5419380)
Affinity DataIC50: 3.70E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627110(CHEMBL5411097)
Affinity DataIC50: 4.00E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627117(CHEMBL5407538)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627109(CHEMBL5418186)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627107(CHEMBL5406556)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627111(CHEMBL5423195)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627113(CHEMBL5422979)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627121(CHEMBL5427281)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627122(CHEMBL5430605)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627123(CHEMBL5401983)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627108(CHEMBL5426005)
Affinity DataIC50: 1.30E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106946(US8592468, EbSe4)
Affinity DataIC50: 1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106945(US8592468, EbSe3)
Affinity DataIC50: 1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50406014(CHEMBL5271737)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of Escherichia coil TrxR incubated for 2 hrs in presence of DTT and insulinMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106947(US8592468, EbSe11)
Affinity DataIC50: 4.00E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50385299(CHEMBL2035464 | US8592468, EbSe16)
Affinity DataKi:  10nM IC50: 2.25E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50385302(CHEMBL2035461 | US8592468, EbSe15)
Affinity DataKi:  40nM IC50: 2.10E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50385303(CHEMBL2035460 | US8592468, EbSe14)
Affinity DataKi:  50nM IC50: 2.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106948(US8592468, EbSe12)
Affinity DataKi:  250nM IC50: 3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106941(US8592468, EbSe8)
Affinity DataKi:  250nM IC50: 6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataKi:  300nM IC50: 6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataKi:  520nMAssay Description:Competitive inhibition of Escherichia coli TrxR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106940(US8592468, EbSe7)
Affinity DataKi:  550nM IC50: 7.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106944(US8592468, EbSe2)
Affinity DataKi:  1.00E+3nM IC50: 1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106942(US8592468, EbSe9)
Affinity DataKi:  1.20E+3nM IC50: 7.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM106949(US8592468, EbSe13)
Affinity DataKi:  1.50E+3nM IC50: 3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB as...More data for this Ligand-Target Pair
In DepthDetails
US Patent