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TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24554(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24555(2-{[4-chloro-6-(2,3-dihydro-1H-inden-4-ylamino)pyr...)
Affinity DataEC50:  3.90E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24556(ethyl 2-{[4-chloro-6-(2,3-dihydro-1H-inden-4-ylami...)
Affinity DataEC50:  3.20E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24557(ethyl 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]py...)
Affinity DataEC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24558(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24559(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24560(2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)
Affinity DataEC50:  4.10E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24562(ethyl 2-{[4-chloro-6-(quinolin-6-yloxy)pyrimidin-2...)
Affinity DataEC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DatapH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22320(ethyl 5-methoxy-1-methyl-2-(4-phenylpiperazin-1-yl...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22321(ethyl 2-[4-(4-fluorophenyl)piperazin-1-yl]-5-hydro...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22323(ethyl 2-(4-benzylpiperazin-1-yl)-5-hydroxy-1H-indo...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22327(methyl 2-[(1-phenylethyl)amino]-1H-indole-3-carbox...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22328(methyl 5-hydroxy-2-[(1-phenylethyl)amino]-1H-indol...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM22333(ethyl 5-hydroxy-2-(pyridin-3-ylamino)-1H-indole-3-...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataEC50:  6.80E+3nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001168(CHEMBL108854 | 3-(Benzothiazol-2-ylsulfanyl)-propy...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001169(CHEMBL320329 | 2-benzo[d][1,3]thiazol-2-ylsulfanyl...)
Affinity DataEC50:  90nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001170(CHEMBL325105 | 5-ethyloxy-2-benzo[d][1,3]thiazol-2...)
Affinity DataEC50:  110nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001172(CHEMBL320030 | 2-benzo[d][1,3]thiazol-2-ylsulfanyl...)
Affinity DataEC50:  130nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50000541(Leutrol | CHEMBL93 | N-(1-Benzo(b)thien-2-ylethyl)...)
Affinity DataEC50:  470nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001174(CHEMBL320275 | 2-(Benzothiazol-2-ylsulfanyl)-ethyl...)
Affinity DataEC50:  5.20E+3nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001178(CHEMBL319002 | 2-(7-Chloro-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  530nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001176(CHEMBL320274 | 2-(5-Chloro-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  20nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001177(CHEMBL110327 | 2-(6-Ethoxy-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  390nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001179(CHEMBL110242 | 3-(Benzothiazol-2-ylsulfanyl)-N-hyd...)
Affinity DataEC50:  130nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001180(CHEMBL108624 | 2-(Benzothiazol-2-ylsulfanyl)-N-hyd...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001181(CHEMBL108204 | 3-(Benzothiazol-2-ylsulfanyl)-N-hyd...)
Affinity DataEC50:  39nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001171(CHEMBL419745 | 3-(Benzothiazol-2-ylsulfanyl)-propy...)
Affinity DataEC50:  45nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001183(3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyr...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001182(CHEMBL110863 | 2-(5-Chloro-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001184(CHEMBL106206 | 2-(6-Isopropyl-benzothiazol-2-ylsul...)
Affinity DataEC50:  160nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001185(CHEMBL108538 | 2-(5-Chloro-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  2.45E+4nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001186(CHEMBL323039 | 2-(5-Trifluoromethyl-benzothiazol-2...)
Affinity DataEC50:  3.20E+3nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001175(CHEMBL110513 | C-(Benzothiazol-2-ylsulfanyl)-methy...)
Affinity DataEC50:  1.07E+3nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50001187(CHEMBL110928 | 3-(5-Chloro-benzothiazol-2-ylsulfan...)
Affinity DataEC50:  20nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50172379((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit 5-lipoxygenase by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50172379((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit 5-lipoxygenase by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM46671(cid_411519 | MLS-0315919.0001 | 2-phenyl-1H-indazo...)
Affinity DataEC50: >4.75E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50008997(CHEMBL412905 | 1-Methyl-1,2-dihydro-indazol-3-one)
Affinity DataEC50: >6.74E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009004(1-Phenyl-pyrazolidin-3-one(phenidone) | 1-phenylpy...)
Affinity DataEC50:  3.08E+4nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009019(2-(6-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Affinity DataEC50:  4.17E+4nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009014(2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one ...)
Affinity DataEC50:  1.13E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50008986(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Affinity DataEC50: >3.46E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009017(2-(4-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Affinity DataEC50:  2.08E+4nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009006(2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one ...)
Affinity DataEC50: >3.64E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009009(2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | CH...)
Affinity DataEC50: >3.96E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50009000(2-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL1984519)
Affinity DataEC50:  8.91E+4nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50008993(CHEMBL8612 | 1-Benzyl-1,2-dihydro-indazol-3-one)
Affinity DataEC50: >4.45E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

LigandPNGBDBM50406480(CHEMBL276476)
Affinity DataEC50: >4.19E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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