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TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50139204(3-[4-(3-Guanidino-benzoylamino)-phenylsulfanyl]-3-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Cell adhesion via integrin alphaIIb-beta3 expressed in CHO cells to fibrinogenMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075579(2-Butoxycarbonylamino-3-{2-[3-(4-carbamimidoyl-phe...)
Affinity DataKd:  2.80nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075566(CHEMBL117989 | CHEMBL275611 | (S)-3-{2-[(R)-3-(4-C...)
Affinity DataKd:  0.600nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075572((S)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  2.70nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075563((R)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  5.90nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075579(2-Butoxycarbonylamino-3-{2-[3-(4-carbamimidoyl-phe...)
Affinity DataKd:  2.40nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075563((R)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  24nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075580((R)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  186nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075580((R)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  253nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075572((S)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  3.70nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50075566(CHEMBL117989 | CHEMBL275611 | (S)-3-{2-[(R)-3-(4-C...)
Affinity DataKd:  0.900nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078431((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataKd:  0.150nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078432((S)-3-[(5-Piperidin-4-yl-thieno[2,3-b]thiophene-2-...)
Affinity DataKd:  22nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078433(2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl-eth...)
Affinity DataKd:  0.150nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078436((S)-2-(2-Ethoxy-ethanesulfonylamino)-3-{[5-(2-pipe...)
Affinity DataKd:  1.20nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataKd:  0.0700nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078438((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[3,2-b]th...)
Affinity DataKd:  0.0920nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078439((S)-2-Methanesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  52nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078443((S)-2-(Butane-1-sulfonylamino)-3-{[5-(2-piperidin-...)
Affinity DataKd:  5.60nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078442(3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1...)
Affinity DataKd:  2.20nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078441((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[3,2-b]th...)
Affinity DataKd:  0.0800nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078435((S)-2-(2-Ethoxy-ethanesulfonylamino)-3-{[5-(2-pipe...)
Affinity DataKd:  1.10nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078447((S)-3-{[5-(3-Piperidin-4-yl-propyl)-thieno[2,3-b]t...)
Affinity DataKd:  17nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078445((S)-2-(Butane-1-sulfonylamino)-3-{[5-(2-piperidin-...)
Affinity DataKd:  3nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  0.0230nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataKd:  15nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078444((S)-2-(4-Chloro-benzenesulfonylamino)-3-{[5-(2-pip...)
Affinity DataKd:  0.0260nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078448(3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1...)
Affinity DataKd:  550nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataEC50:  13.6nMAssay Description:Inhibition of integrin alpha2bbeta3-mediated platelet aggregation in human TRAP-6-activated whole blood for 6 mins by impedence-based aggregometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50365350(CHEMBL1956154)
Affinity DataEC50:  40.8nMAssay Description:Inhibition of integrin alpha2bbeta3-mediated platelet aggregation in human TRAP-6-activated whole blood for 6 mins by impedence-based aggregometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50365352(CHEMBL1956152)
Affinity DataEC50:  276nMAssay Description:Inhibition of integrin alpha2bbeta3-mediated platelet aggregation in human TRAP-6-activated whole blood for 6 mins by impedence-based aggregometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50365354(CHEMBL1956150)
Affinity DataEC50:  7.80nMAssay Description:Inhibition of integrin alpha2bbeta3-mediated platelet aggregation in human TRAP-6-activated whole blood for 6 mins by impedence-based aggregometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058237((S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-pipe...)
Affinity DataKd:  1.40nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058238(CHEMBL540024 | CHEMBL288521 | 3-{[4-Oxo-5-(2-piper...)
Affinity DataKd:  590nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50033030(3-{2-[2-Oxo-3-(2-piperidin-4-yl-ethyl)-piperidin-1...)
Affinity DataKd:  600nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058236((S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-pipe...)
Affinity DataKd:  1.80nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058240(3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-tetra...)
Affinity DataKd:  680nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058239((S)-3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-t...)
Affinity DataKd:  1.10nMAssay Description:Displacement of L-736,622 from purified resting Fibrinogen ReceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078448(3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1...)
Affinity DataKd:  550nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078433(2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl-eth...)
Affinity DataKd:  0.150nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50033030(3-{2-[2-Oxo-3-(2-piperidin-4-yl-ethyl)-piperidin-1...)
Affinity DataKd:  650nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078442(3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1...)
Affinity DataKd:  2.20nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058236((S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-pipe...)
Affinity DataKd:  1.40nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataKd:  0.0700nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50033030(3-{2-[2-Oxo-3-(2-piperidin-4-yl-ethyl)-piperidin-1...)
Affinity DataKd:  4.5nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin activated plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50091734(3-{2-[Cyclopropyl-(3-piperidin-4-yl-benzoyl)-amino...)
Affinity DataKd:  120nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  0.0900nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50091741((S)-4-Hydroxy-3-[2-(1-oxo-7-piperazin-1-yl-3,4-dih...)
Affinity DataKd:  15nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50091737(2-Benzenesulfonylamino-3-[4-(2-piperidin-4-yl-etho...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50058240(3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-tetra...)
Affinity DataKd:  46nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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