Compile Data Set for Download or QSAR
Report error Found 1270 of affinity data for UniProtKB/TrEMBL: P07943
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50487936(CHEBI:48480 | CHEMBL2261578)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50122956([2,4-Bis-(4-methoxy-benzoyl)-pyrrol-1-yl]-acetic a...)
Affinity DataIC50: 2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50122956([2,4-Bis-(4-methoxy-benzoyl)-pyrrol-1-yl]-acetic a...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50487916(CHEMBL2261575)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM16496(CHEMBL10413 | FR 74366 | [3-(4-bromo-2-fluorobenzy...)
Affinity DataIC50: 4.40nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50010282(CHEMBL418832 | 2,7-difluorospiro[9H-fluorene-9,3'-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50056538({3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DI...)
Affinity DataIC50: 5.70nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50563402(CHEMBL4782479)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50487917(CHEMBL2261574)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50010282(CHEMBL418832 | 2,7-difluorospiro[9H-fluorene-9,3'-...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50563408(CHEMBL4743085)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 10nMAssay Description:Compound was tested for the inhibition of the rat lens aldose reductase using the substrate as glucose.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50056534([3-(4-Chloro-benzothiazol-2-ylmethyl)-2,4-dioxo-3,...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50563399(CHEMBL4749891)
Affinity DataIC50: 11nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50056531([3-(4-Chloro-benzothiazol-2-ylmethyl)-2,4,5-trioxo...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50056540([3-(5-Chloro-benzothiazol-2-ylmethyl)-2,4,5-trioxo...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50056535([3-(4-Chloro-3-nitro-benzyl)-2,4,5-trioxo-imidazol...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009777(Ponalrestat (statil) | CHEMBL7679 | [3-(4-Bromo-2-...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 17nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 17nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50015588(CHEMBL3260158)
Affinity DataIC50: 18nMAssay Description:Inhibition of aldose reductase in rat lens by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50015589(CHEMBL3260160)
Affinity DataIC50: 18nMAssay Description:Inhibition of aldose reductase in rat lens by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50010281(CHEMBL327139 | 2,7-Difluorospiro[9H-fluorene-9,5'-...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 20nMAssay Description:Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022179((3-Oxo-3H-benzo[f]chromen-1-yl)-acetic acid | CHEM...)
Affinity DataIC50: 20nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009777(Ponalrestat (statil) | CHEMBL7679 | [3-(4-Bromo-2-...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50435110(CHEMBL2391535)
Affinity DataIC50: 20nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50498624(CHEMBL3609180)
Affinity DataIC50: 20nMAssay Description:Inhibition of Wistar rat ALR2 using D,L-glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity against partially purified rat lens Aldose reductase at a dose of 5e-7MMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50435110(CHEMBL2391535)
Affinity DataIC50: 21nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50563412(CHEMBL4746398)
Affinity DataIC50: 21nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50260962(CHEMBL4075185)
Affinity DataIC50: 22nMAssay Description:Inhibition of AR in Sprague-Dawley rat lens using DL-glyceraldehyde as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50563415(CHEMBL4786411)
Affinity DataIC50: 22nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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