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Report error Found 668 for UniProtKB: P05362
TargetIntegrin alpha-L/Intercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50157352(1-{6-[4-(2-Isopropyl-phenylsulfanyl)-3-trifluorome...)
Affinity DataEC50:  90nMAssay Description:Effective concentration to measure the adherence of LFA-1 expressing JY8 cells to immobilized ICAM-1 in cell-based adhesion assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/Intercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50157359(4-[4-(2-Isopropyl-phenylsulfanyl)-3-trifluoromethy...)
Affinity DataEC50:  20nMAssay Description:Effective concentration to measure the adherence of LFA-1 expressing JY8 cells to immobilized ICAM-1 in cell-based adhesion assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105186(4-(4-Trifluoromethyl-phenoxy)-thieno[2,3-c]pyridin...)
Affinity DataIC50: 1nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105227(4-[4-(Tetrahydro-pyran-2-yloxymethyl)-phenoxy]-thi...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory potency compared to IL1-beta induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105151(4-(4-Vinyl-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 2nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105215(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 2nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386338(CHEMBL2048036)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50386331(CHEMBL2048028)
Affinity DataIC50: 2.98nMAssay Description:Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory potency compared to IL1-beta induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50199036(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386328(CHEMBL2048025)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105155(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105195(4-(4-Pyrazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105178(4-(4-Iodo-phenoxy)-thieno[2,3-c]pyridine-2-carboxy...)
Affinity DataIC50: 4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105196(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386325(CHEMBL2048402)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105183(4-(4-Furan-2-yl-phenoxy)-thieno[2,3-c]pyridine-2-c...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory potency compared to PMA induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105180(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105205(4-(4-Imidazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099130(1-[2-(2,3-Dichloro-4-{2-[3-(2-oxo-pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099130(1-[2-(2,3-Dichloro-4-{2-[3-(2-oxo-pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105164(4-(4-Thiophen-2-yl-phenoxy)-thieno[2,3-c]pyridine-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory potency compared to PMA induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105172(4-[4-(2-Methoxy-ethoxymethyl)-phenoxy]-thieno[2,3-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105201(4-(4-Imidazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50199031(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386326(CHEMBL2048024)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099134(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099134(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099129(2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phe...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099129(2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phe...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099132(4-({2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)...)
Affinity DataIC50: 7nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099132(4-({2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)...)
Affinity DataIC50: 7nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50098517(4-(3,4-Dimethyl-phenylsulfanyl)-thieno[2,3-c]pyrid...)
Affinity DataIC50: 8nMAssay Description:In vitro potency against TNF alpha induced expression of intercellular adhesion molecule-1 on human vascular endothelial cells using CAM ELISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105207(4-[4-(2-Methoxy-ethoxymethyl)-phenoxy]-thieno[2,3-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50199037(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105181(4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 9nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386331(CHEMBL2048028)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099135(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 9nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50099135(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 9nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50098480(4-(4-Bromo-phenylsulfanyl)-thieno[2,3-c]pyridine-2...)
Affinity DataIC50: 10nMAssay Description:In vitro potency against TNF alpha induced expression of intercellular adhesion molecule-1 on human vascular endothelial cells using CAM ELISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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