Compile Data Set for Download or QSAR
Report error Found 170 for UniProtKB: P05181
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50437753(CHEMBL2409564)
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92665(Auxiliary substrate, 10a)
Affinity DataKd:  2.60E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92666(Auxiliary substrate, 11a)
Affinity DataKd:  1.80E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92667(Auxiliary substrate, 12a)
Affinity DataKd:  5.90E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92668(Auxiliary substrate, 1a)
Affinity DataKd:  1.40E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92669(Auxiliary substrate, 14a)
Affinity DataKd:  2.10E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92670(Auxiliary substrate, 16a)
Affinity DataKd:  1.30E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92671(Auxiliary substrate, 18a)
Affinity DataKd:  1.20E+4nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92672(Auxiliary substrate, 20a)
Affinity DataKd:  1.60E+3nMAssay Description:All UV/Vis spectra of the enzyme-ligand complexes were obtained on a Cary 5000 UV/Vis spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92497(CHEMBL542051 | Omega-imidazolyl octanoic acid)
Affinity DataKd:  2.10E+4nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92498(Omega-imidazolyl decanoic acid)
Affinity DataKd:  9.00E+3nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM92499(Omega-imidazolyl dodecanoic acid)
Affinity DataKd:  1.80E+3nMAssay Description:Binding assay using CYP2E1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366426(CHEMBL4161819)
Affinity DataIC50: 230nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158914(US8609708,12 | cid_11207072 | CHEMBL178780 | 3-(1-...)
Affinity DataIC50: 580nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50110231(3-(3-Nitro-phenyl)-3-{2-[4-(pyridin-2-ylamino)-but...)
Affinity DataIC50: 850nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50010231(CHEMBL107217 | sodium diethyldithiocarbamate | sod...)
Affinity DataIC50: 850nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158925(Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amine | C...)
Affinity DataIC50: 860nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366334(CHEMBL4173133)
Affinity DataIC50: 920nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366407(CHEMBL4169324)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366379(CHEMBL4165249)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366401(CHEMBL4169721)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366410(CHEMBL4163694)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366393(CHEMBL4176100)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366399(CHEMBL4168669)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158919(US8609708, 33 | CHEMBL179618 | 3-Thiophen-2-yl-pyr...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158920(3-(3-Methyl-1H-imidazol-4-yl)-pyridine | CHEMBL179...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM12352(US8609708, 5 | cid_11344157 | 3-(1-methyl-1H-imida...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158923(CHEMBL178534 | US8609708, 18 | 5-Pyridin-3-yl-thio...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366406(CHEMBL4174365)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366402(CHEMBL4172462)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM19188(CHEMBL593763 | C18 | 7-[(3-chlorophenyl)methoxy]-4...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366411(CHEMBL4160749)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366404(CHEMBL4162449)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM12358(US8609708, 17 | US8609708,17 | CHEMBL179704 | 3-(4...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366395(CHEMBL4175869)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM12351(US8609708, 4 | CHEMBL179669 | 3-(3-methylthiophen-...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366394(CHEMBL4159065)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50158913(US8609708, 28 | CHEMBL179005 | 2-Fluoro-5-thiophen...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50: 9.20E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50: 9.20E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366435(CHEMBL4161400)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50017203(CHEMBL3287379)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396352(CHEMBL2170062)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396352(CHEMBL2170062)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50236754(CHEMBL4082473)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50341408(CHEMBL4166594 | US11534443, Example 29)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50341416(CHEMBL4174909 | US11534443, Example 32)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50341409(CHEMBL4176771 | US11534443, Example 9)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as reduction in 6-Hydroxychlorzoxazone formation using chlorzoxazone as substrate after 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50452361(CHEMBL4218749)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2E1 expressed in yeast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Displayed 1 to 50 (of 170 total ) | Next | Last >>
Jump to: