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TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272397((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  15.9nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272432((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272400((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  18nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272399((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  22nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272398((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  18.7nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272523((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  4.90nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272522((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  21.5nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272521(Adamantan-1-yl-carbamic acid (8S,9R,10S,11S,13S,14...)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272520((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272494((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  2.80nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272493((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  23.2nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272492((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  21nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272470((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272469((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  53.3nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272468((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272435((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  83nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272434((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272433((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  39nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataKd:  5.18E+4nMAssay Description:Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240896(CHEMBL163316 | 3',4',5,7-tetrahydroxy-3-methoxyfla...)
Affinity DataKd:  2.17E+4nMAssay Description:Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137279(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072583((2R,3S)-2,N*1*-Dihydroxy-N*4*-[(S)-1-(1H-indole-3-...)
Affinity DataIC50: 0.260nMAssay Description:In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50: 0.300nMAssay Description:Activity against Matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.400nMAssay Description:Activity against Matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082537((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-thi...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082543((S)-4-(4-bromo-2-methylphenylsulfonyl)-N-hydroxy-2...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50290085((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human collagenase (MMP1)More data for this Ligand-Target Pair
In DepthDetails Article

TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082541((S)-4-(4-bromophenylsulfonyl)-N-hydroxy-2,2-dimeth...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataIC50: 0.780nMAssay Description:In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082991((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.880nMAssay Description:Inhibitory activity against MMP-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082534((S)-2,2-Dimethyl-4-(5-pyridin-2-yl-thiophene-2-sul...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082550((S)-4-(4-Methoxy-benzenesulfonyl)-6-methoxymethoxy...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50290088((2S,3R)-N*1*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human collagenase (MMP1)More data for this Ligand-Target Pair
In DepthDetails Article

TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102750(CHEMBL3359091)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50622040(CHEMBL5394834)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50622041(CHEMBL4859817)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50622043(CHEMBL5426756)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50622044(CHEMBL5413816)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
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