| Assay Method Information | |
| | Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Joel Buxbaum, The Scripps Research Institute (TSRI) Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R21AG041496 Grant Proposal PI: Joel Buxbaum, The Scripps Research Institute (TSRI) External Assay ID: TTR_ACT_LUMI_1536_3XEC50 DRUN Name: Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription Description: The "Amyloid Hypothesis" of human Alzheimer's disease (AD) is based on human genetic data, murine models in which mutant human Amyloid-B Precursor Protein (ABPP) and/or presenilins are expressed, and in vitro and tissue culture evidence indicating that aggregation of various forms of the neuronal ABPP cleavage product AB1-40/42 plays a major role in the pathogenesis of autosomal dominant and sporadic forms o |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |