| Assay Method Information | |
| | Radioligand Binding Assay |
| Description: | The new compounds have been tested by radioligand binding competition activity at the human 5-HT1A (FAST-0500B), 5-HT2A (FAST-0505B), 5-HT2Cedited (FAST-0507B), 5-HT6 (FAST-0509B), 5-HT7a (FAST-05111B) and D2(long) (FAST-0101B) receptors at seven (7) concentrations, in duplicate. On each day of experimentation, reference compounds were tested at several concentrations in duplicate (n=2) to obtain a dose-response curve and an estimated EC50/IC50 value. Reference values thus obtained for the test were compared to historical values obtained from the same receptor and used to validate the experimental session. For replicate determinations, the maximum variability tolerated in the test was of +/- 20% around the average of the replicates. |
| Affinity data for this assay | |
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