| Assay Method Information | |
| | Inhibitory Assay |
| Description: | Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in combination with other drugs, there was almost no possibility of drug-drug interactions caused by OAT3 (superior to positive drug probenecid). The compounds and the positive drug probenecid had a certain inhibitory effect on the drug transporters OAT1 and OAT4, and when the compounds were used clinically in combination with other drugs, there was the possibility of drug-drug interactions caused by OAT1 and OAT4, but the inhibitory effect of the compounds was weaker than that of the positive drug probenecid, so the clinical safety risk was lower. |
| Affinity data for this assay | |
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