Reaction Details  Report a problem with these data
Cell Reactant:
Bromodomain-containing protein 4 (BRD4)
Syringe Reactant:
BDBM50365262
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2016-12-15
ΔG°:
-10.13±n/a (kcal/mole)
Temperature:
298.1500±0.0000 (K)
ΔH° :
-6.81±0.07 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Citation
 Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Cell React
Name:
Bromodomain-containing protein 4 [44-168]
Synonyms:
BET bromodomain 4(1) (BRD4(1)) | BRD4-BD1 protein (aa 44-168) | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | BRD4_HUMAN | BRD4 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14866.49
Organism:
Human
Description:
aa (44-168)
Residue:
125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Syringe React
Name:
BDBM50365262
Synonyms:
CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 | US9695172, JQ1 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10925881, Name (S)-JQ1 | US10881668, Compound JQ1 | US11020380, Example JQ-1 | (+)-JQ1 | US11078188, Example (+)-JQ1 | US11466034, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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