Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
Serine/threonine-protein kinase Aurora-A
Syringe Reactant:
BDBM87050
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2012-06-18
pH:
7.4000±0.0000
Temperature:
298.1500±0.0000 (K)
ΔH° :
-14.11±0 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Citation
Martin, MP; Zhu, JY; Lawrence, HR; Pireddu, R; Luo, Y; Alam, R; Ozcan, S; Sebti, SM; Lawrence, NJ; Schönbrunn, E A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS Chem Biol 7:698-706 (2012) [PubMed] Article More Info.:
Cell React
Name:
Aurora kinase A
Synonyms:
AURKA_HUMAN | AIRK1 | hARK1 | STK15 GN | STK6 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Synonyms=AIK | AURKA | Breast tumor-amplified kinase | STK15 | Serine/threonine kinase 15 | Breast-tumor-amplified kinase | Serine/threonine-protein kinase aurora-A | Aurora kinase A (AURKA) | AYK1 | aurora-2 | AIK | BTAK | ARK-1 | Aurora kinase A (AURA) | ARK1 | Aurora/IPL1-related kinase 1 | Aurora 2 | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora kinase A (Aurora A) | Serine/threonine-protein kinase aurora A | IAK1 | AURA
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Human
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Syringe React
Name:
BDBM87050
Synonyms:
Bisanilinopyrimidine, 6h | Bisanilinopyrimidine inhibitor, 4 | US9249124, 31
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
