Reaction Details  Report a problem with these data
Cell Reactant:
Grp78
Syringe Reactant:
BDBM32373
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2011-12-08
pH:
7.4000±0.0000
Log10Kb:
-∞
Temperature:
298.1500±0.0000 (K)
ΔH° :
-12.42±0 (kJ/mole)
ΔS° :
-0.01±0 (kJ/mole-K)
Citation
 Macias, AT; Williamson, DS; Allen, N; Borgognoni, J; Clay, A; Daniels, Z; Dokurno, P; Drysdale, MJ; Francis, GL; Graham, CJ; Howes, R; Matassova, N; Murray, JB; Parsons, R; Shaw, T; Surgenor, AE; Terry, L; Wang, Y; Wood, M; Massey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem 54:4034-41 (2011) [PubMed]  Article 
Cell React
Name:
Endoplasmic reticulum chaperone BiP
Synonyms:
Heat shock protein family A member 5 | HSPA5 | HSP70 family protein 5 | BiP | GRP78 | 3.6.4.10 | 78 kDa glucose-regulated protein | Synonyms=GRP78 | Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 | BIP_HUMAN | Heat shock 70 kDa protein 5 | Immunoglobulin heavy chain-binding protein | Heat shock protein 70 family protein 5 | Binding-immunoglobulin protein | GRP-78
Type:
n/a
Mol. Mass.:
72312.92
Organism:
Human
Description:
P11021
Residue:
654
Sequence:
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
  
Syringe React
Name:
BDBM32373
Synonyms:
adenosine-derived inhibitor (Grp78), 8 | adenosine-derived inhibitor, 7
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: