Reaction Details  Report a problem with these data
Cell Reactant:
DNA Gyrase
Syringe Reactant:
BDBM282
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2003-03-31
ΔG°:
-10.22±0.12 (kcal/mole)
pH:
7.5000±n/a
Log10Kb:
6.9
Temperature:
298.1500±n/a (K)
ΔH° :
-12.39±1 (kJ/mole)
ΔHobs :
-12.39±1 (kJ/mole)
Corrected for ΔHioniz:
not known
ΔCp :
-0.29±n/a (kJ/mole)
ΔS° :
-0.01±0 (kJ/mole-K)
Citation
 Lafitte, D; Lamour, V; Tsvetkov, PO; Makarov, AA; Klich, M; Deprez, P; Moras, D; Briand, C; Gilli, R DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry 41:7217-23 (2002) [PubMed]  Article
Cell React
Source:
Bacterial clone
Purity:
97%
Name:
DNA gyrase subunit B
Synonyms:
gyrB
Type:
Enzyme
Mol. Mass.:
89941.28
Organism:
Escherichia coli
Description:
C3SLN3
Residue:
804
Sequence:
MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI
  
Syringe React
Name:
BDBM282
Synonyms:
Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzene]amido}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyloxan-4-yl carbamate | Novobiocin | US20230364057, Compound Novobiocin
Type:
Antibiotic
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: