Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50008485
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  0.690nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi:  9.90nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073753((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory activity against recombinant human Thymidylate synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073752(LY-335580 | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetr...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50073754((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Affinity DataKi:  5.60E+4nMAssay Description:Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed