Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50007658
TargetGrowth hormone secretagogue receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKd:  0.140nMAssay Description:Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGrowth hormone secretagogue receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066101(Piperidine-4-carboxylic acid {1-[1-(carbamoylmethy...)
Affinity DataEC50:  0.340nMAssay Description:Compound was evaluated for GH release for effect on human GH secretagogue receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066086(1N-{6-[1'-[2-(1-amino-1-methylethylcarboxamido)-3-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066092(L-368112 | 3N-[7,7-dimethyl-1-spiro[2,3-dihydro-1H...)
Affinity DataIC50: 68nMAssay Description:Antagonistic activity against Oxytocin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066084(3N-[7,7-dimethyl-1-spiro[2,3-dihydro-1H-indene-1,4...)
Affinity DataIC50: 130nMAssay Description:Antagonistic activity against Oxytocin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed