Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 286
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM194((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxy-...)
Affinity DataKi:  0.00500nM ΔG°:  -65.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM195(Azacyclic Urea | (5R,6R)-1,5-dibenzyl-2-(cycloprop...)
Affinity DataKi:  0.0620nM ΔG°:  -59.2kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM192((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxyp...)
Affinity DataKi:  0.0700nM ΔG°:  -58.9kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM189(Azacyclic Urea | (5R,6R)-2,4-Bis[(hydroxymethyl)be...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM193(Azacyclic Urea | (5R,6R)-1,5-dibenzyl-6-hydroxy-2,...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM190(Azacyclic Urea | (5R,6R)-5-benzyl-1-(furan-3-ylmet...)
Affinity DataKi:  0.490nM ΔG°:  -54.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM191(Azacyclic Urea | (5R,6R)-1,2,4,5-tetrabenzyl-6-hyd...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2002
Entry Details Article
PubMed