Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50005907
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029766(2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)
Affinity DataIC50: 0.580nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 7.40nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029766(2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042352(5-Methyl-6-[(3,4,5-trichloro-phenylamino)-methyl]-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029766(2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042354(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50031870(6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5-...)
Affinity DataIC50: 27nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042351(6-[(3,4-Dichloro-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50: 28nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042352(5-Methyl-6-[(3,4,5-trichloro-phenylamino)-methyl]-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042355(5-Methyl-6-{[methyl-(3,4,5-trichloro-phenyl)-amino...)
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration against Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042355(5-Methyl-6-{[methyl-(3,4,5-trichloro-phenyl)-amino...)
Affinity DataIC50: 36nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042355(5-Methyl-6-{[methyl-(3,4,5-trichloro-phenyl)-amino...)
Affinity DataIC50: 38nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 38nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 42nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50031870(6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042351(6-[(3,4-Dichloro-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50: 53nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042352(5-Methyl-6-[(3,4,5-trichloro-phenylamino)-methyl]-...)
Affinity DataIC50: 63nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042353(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 83nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 86nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 94nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50031870(6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5-...)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042355(5-Methyl-6-{[methyl-(3,4,5-trichloro-phenyl)-amino...)
Affinity DataIC50: 105nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042354(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 110nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042353(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 140nMAssay Description:Inhibitory concentration against rat liver dihydrofolate reductasesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029766(2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 250nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042351(6-[(3,4-Dichloro-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50: 320nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042353(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 510nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 520nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042354(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 550nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042351(6-[(3,4-Dichloro-phenylamino)-methyl]-5-methyl-pyr...)
Affinity DataIC50: 860nMAssay Description:Inhibitory concentration against Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50031870(6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5-...)
Affinity DataIC50: 960nMAssay Description:Inhibitory concentration against Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042358(N-(2,4-Diamino-5-methyl-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042358(N-(2,4-Diamino-5-methyl-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042359(N-(2,4-Diamino-5-methyl-5,8-dihydro-pyrido[2,3-d]p...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042359(N-(2,4-Diamino-5-methyl-5,8-dihydro-pyrido[2,3-d]p...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042356(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042356(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-y...)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibitory concentration required to decrease cell viability in cell growth culture against breast carcinoma cells MCF-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory concentration against rat liver (RL) dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)