Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50021802
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50602410(CHEMBL5173274)
Affinity DataIC50: 8.10nMAssay Description:Covalent inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 18nMAssay Description:Covalent inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataIC50: 19nMAssay Description:Covalent inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataKd:  130nMAssay Description:Binding affinity to recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells assessed as dissociation constant me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50602444(CHEMBL5206501)
Affinity DataIC50: 310nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645043(CHEMBL5589829)
Affinity DataKd:  700nMAssay Description:Binding affinity to recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells assessed as dissociation constant me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645046(CHEMBL5568874)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645043(CHEMBL5589829)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645047(CHEMBL5572124)
Affinity DataIC50: 1.15E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 30 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50342561((2-oxoindolin-3-ylidene)indolin-2-one | (E)-[3,3'-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645044(CHEMBL5573244)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645046(CHEMBL5568874)
Affinity DataKd:  1.27E+3nMAssay Description:Binding affinity to recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells assessed as dissociation constant me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645047(CHEMBL5572124)
Affinity DataIC50: 1.30E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 10 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645047(CHEMBL5572124)
Affinity DataIC50: 1.34E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 50 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645047(CHEMBL5572124)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645046(CHEMBL5568874)
Affinity DataIC50: 1.49E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 50 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645046(CHEMBL5568874)
Affinity DataIC50: 1.52E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 30 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645045(CHEMBL5565973)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645046(CHEMBL5568874)
Affinity DataIC50: 1.96E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main protease incubated for 10 mins followed by substrate addition by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataIC50: 2.50E+3nMAssay Description:Non-covalent inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636305(MEISOINDIGO)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Central South University

Curated by ChEMBL
LigandPNGBDBM50645047(CHEMBL5572124)
Affinity DataKd:  1.68E+4nMAssay Description:Binding affinity to recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 DE3 expression cells assessed as dissociation constant me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed