Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50020704
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.0360nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of HDAC1 in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of HDAC1 in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of HDAC1 in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632921(CHEMBL5408205)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 7nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632922(CHEMBL5436744)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 21nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50: 23nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 25nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 27nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 34nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 41nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 47nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 50nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 59nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 74nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolyamine deacetylase HDAC10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 116nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolyamine deacetylase HDAC10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 127nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 137nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolyamine deacetylase HDAC10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 145nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 201nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 299nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 303nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 312nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 322nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 414nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 595nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632923(CHEMBL5433552)
Affinity DataIC50: 724nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 780nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 931nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 954nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632924(CHEMBL5395502)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
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