Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50020151
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  8nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as dissociation constant incubated for 30 mins by streptavidin pulldown based Western blot analys...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  14nMAssay Description:Binding affinity to TNKS1 (unknown origin) assessed as dissociation constant incubated for 30 mins by streptavidin pulldown based Western blot analys...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626785(CHEMBL5396891)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM209932(Veliparib | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-be...)
Affinity DataIC50: 0.0610nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626790(CHEMBL5411446)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626789(CHEMBL5441085)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626791(CHEMBL5435531)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626792(CHEMBL5411930)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626788(CHEMBL5428997)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50535017(CHEMBL4458889)
Affinity DataIC50: 13nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50535024(CHEMBL4590570)
Affinity DataIC50: 19nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50609913(CHEMBL5274451)
Affinity DataIC50: 19nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PARP1 (unknown origin) using Streptavidin-HRP as substrate incubated for 1 hr by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626787(CHEMBL5417122)
Affinity DataIC50: 37nMAssay Description:Inhibition of PARP1 (unknown origin) using Streptavidin-HRP as substrate incubated for 1 hr by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50536941(CHEMBL4521985)
Affinity DataIC50: 79nMAssay Description:Inhibition of human N-terminal His6-tagged PARP1 CD (662 to 1011 residues) expressed in Escherichia coli BL21 incubated for 60 mins by chemiluminesce...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50536938(CHEMBL4521684)
Affinity DataIC50: 97nMAssay Description:Inhibition of PARP1 CD (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626793(CHEMBL5413935)
Affinity DataIC50: 240nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50432331(CHEMBL2347906)
Affinity DataIC50: 530nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50442526(CHEMBL2440673)
Affinity DataIC50: 560nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50442529(CHEMBL2440886)
Affinity DataIC50: 720nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626795(CHEMBL5427942)
Affinity DataIC50: 960nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626794(CHEMBL1358885)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50020712(CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PARP1 CD (662 to 1011 residues) expressed in Escherichia coli BL21 incubated for 60 mins by chemiluminesce...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Niper Guwahati

Curated by ChEMBL
LigandPNGBDBM50626786(CHEMBL5433754)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 60 mins by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed