Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50018940
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613996(CHEMBL5281961)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585727(US11530213, Example 48 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613997(CHEMBL5280047)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585709(US11530213, Example 30 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613999(CHEMBL5289977)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585682(US11530213, Example 3 | 8-chloro-1-(2,6-dichloroph...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50614001(CHEMBL5278366)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GIRK1/2 (unknown origin) channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50614002(CHEMBL5285569)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613994(CHEMBL5269440)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585699(US11530213, Example 20 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human GIRK1/2 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613995(CHEMBL5290509)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585688(US11530213, Example 9 | 8-chloro-1-(2,6-dichloroph...)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50614000(CHEMBL5286244)
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG protein-activated inward rectifier potassium channel 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613998(CHEMBL5277008)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585681(US11530213, Example 2 | (R)-8-chloro-1-(2,6- dichl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed